EARLY LIFE STRESS IN NON-HUMAN PRIMATES AND HUMANS

非人类灵长类动物和人类的早期生活压力

• 批准号: 8357567
• 负责人: MICHAEL NMN DAVIS
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357567
• 关键词: Funding; Grant; Human; Learning; Life Stress; Macaca mulatta; Measures; Monkeys; National Center for Research Resources; Patients; Post-Traumatic Stress Disorders; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Resources; Safety; Signal Transduction; Source; Symptoms; Testing; United States National Institutes of Health; Work; cost; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the reporting period, in other work we found that patients with PTSD do not show normal conditioned inhibition which means we have an objective measure of one of the core symptoms of PTSD, namely the inability to feel safe. We have set up the AX+, BX- in rhesus monkeys at Yerkes and have found good safety signal learning in 3 control and 1 maternally separated monkeys. In the other two separated monkeys they failed show inhibitory learning. This work will now continue in 34 more monkeys funded by a Challenge grant for which I hired a new non-human primate technician, to do this work. She has now completed testing on 12 more monkeys and is almost done with another 6 monkeys.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在报告期间，在其他工作中，我们发现PTSD患者没有表现出正常的条件抑制作用，这意味着我们对PTSD的核心症状之一有客观衡量，即无法感到安全。 我们已经在Yerkes的恒河猴中建立了AX+，BX-，并在3个控制和1个母体分离的猴子中发现了良好的安全信号学习。 在其他两个分离的猴子中，他们未能显示出抑制性学习。 现在，这项工作将继续持续34个猴子，该猴子由挑战补助金资助，我雇用了一位新的非人类灵长类动物技术员来完成这项工作。 她现在已经完成了另外12只猴子的测试，几乎用另外6只猴子完成了测试。