ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE

恐惧增强惊吓的解剖学和药理学

• 批准号: 8357417
• 负责人: MICHAEL NMN DAVIS
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357417
• 关键词: Anatomy; Cues; Diagnosis; Fright; Funding; Grant; Mental Depression; National Center for Research Resources; Patients; Pharmaceutical Preparations; Pharmacology; Post-Traumatic Stress Disorders; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Resources; Sirolimus; Source; United States National Institutes of Health; conditioning; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the reporting period we found that the drug rapamycin blocks consolidation of context but not cue conditioning. We found that patients with PTSD have a selective deficit in inhibition of fear not seen in depression, a major co-morbid diagnosis of PTSD.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 在报告期间，我们发现药物雷帕霉素会阻止上下文的整合，但不能阻止提示条件。 我们发现，PTSD患者在抑制抑郁症中没有恐惧的恐惧（PTSD）的主要合并诊断中存在选择性缺陷。