The Effect of Gonadal Steriods on Pavlovian Fear Conditioning

性腺类固醇对巴甫洛夫恐惧调节的影响

• 批准号: 7537758
• 负责人: MICHAEL NMN DAVIS
• 金额: $ 18.8万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7537758
• 关键词: Acoustics; Address; Affect; Agonist; Androgen Receptor; Androstenediol; Androstenediols; Animals; Anxiety; Anxiety Disorders; Applications Grants; Behavioral; Brain; Cognition; Cues; Data; Development; Discrimination; Discrimination Learning; Disease; Elements; Emotional; Emotions; Estrogen Receptors; Estrogens; Etiology; Exploratory/Developmental Grant; Female; Fright; Gender; Gonadal Hormones; Gonadal Steroid Hormones; Hippocampal Formation; Hippocampus (Brain); Hormones; Human; Individual; Investigation; Laboratories; Learning; Measures; Membrane; Memory; Mental Depression; Metabolism; Methodology; Methods; Modeling; Panic Disorder; Pathology; Pharmaceutical Preparations; Physiological; Play; Post-Traumatic Stress Disorders; Process; Protocols documentation; Public Health; Purpose; Rattus; Reporting; Role; Selective Estrogen Receptor Modulators; Sex Characteristics; Stanolone; Steroids; System; Testosterone; Thinking; Time; Training; Woman; base; conditioned fear; conditioning; hormone regulation; male; men; receptor; response; sex; showing emotion; steroid hormone

DESCRIPTION (provided by applicant): Disorders of anxiety and fear dysregulation are highly prevalent. It is known that these disorders affect women approximately two times more than they affect men, and this disparity is thought to be related to hormone regulation, yet the underlying mechanism of hormone regulation of the fear circuit in either sex remains unknown. The purpose of this Exploratory/ Developmental Grant proposal, in response to PA-03-169, is to develop a more informative and accurate method to determine the effect that gonadal hormones have on fear in both male and female animals. Here, we will employ a new adapted version of the discrimination training paradigm AX+.BX-, along with the use of highly specific estrogen receptor agonists and an androgen receptor-specific testosterone metabolite, to measure the effect that activation of specific gonadal steroid receptors have on both the activation and inhibition of fear. The specific aims of this project are: 1. to validate the use of the AX+, BX- discrimination learning paradigm as a model for examining hormone modulation of fear acquisition, expression and inhibition. 2. to use this model to examine: the effect of gonadal steroids on fear acquisition, and the effect of gonadal steroids on fear expression, in gonadectomized male and female rats. Data from these studies will begin to elucidate the specific effects that these steroid hormones have on very particular aspects of emotional memory formation and expression in general, and moreover, these studies will help to clarify the contribution that the various gonadal steroids make to fear learning in each individual sex . Results from these investigations would not only speak to the development, and expression of emotional learning within each individual sex, but will also begin to address the gender disparity in the occurrence of PTSD, depression and anxiety illness, and panic disorder.

描述（由申请人提供）：焦虑和恐惧失调的疾病非常普遍。众所周知，这些疾病影响女性的影响是男性的两倍，而这种差异被认为与激素调节有关，但是两性中恐惧回路的激素调节的基本机制仍然未知。这项探索/发展赠款提案的目的是对PA-03-169的响应，是开发一种更有信息和准确的方法，以确定性腺激素对雄性和雌性动物的恐惧的影响。在这里，我们将采用一种新的改编版本的歧视训练范式AX+.bx-，以及使用高度特异的雌激素受体激动剂和雄激素受体特异性睾丸激素代谢物，以衡量特定的性腺类固醇受体具有具有特定性腺类固醇受体具有的激活关于恐惧的激活和抑制。该项目的具体目的是：1。验证使用AX+，BX-歧视学习范式作为检查恐惧获取，表达和抑制的激素调节的模型。 2。使用该模型检查：性腺类固醇对恐惧的恐惧的影响，以及性腺类固醇对恐惧表达的影响，在性腺切除型雄性和雌性大鼠中。这些研究的数据将开始阐明这些类固醇激素对情绪记忆形成和表达的非常特定方面的特定作用，此外，这些研究将有助于阐明各种性腺类固醇对恐惧在学习中害怕学习的贡献。每个性别。这些调查的结果不仅可以说明每种性别内情绪学习的发展和表达，而且还将开始解决PTSD，抑郁症和焦虑疾病以及恐慌症的性别差异。