ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE

恐惧增强惊吓的解剖学和药理学

• 批准号: 7715729
• 负责人: MICHAEL NMN DAVIS
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715729
• 关键词: Amygdaloid structure; Anatomy; Anxiety; Brain; Brain-Derived Neurotrophic Factor; CREB1 gene; Cell Nucleus; Computer Retrieval of Information on Scientific Projects Database; Cues; Fright; Funding; Gonadal Steroid Hormones; Grant; Institution; Learning; Medial; Mediating; Modeling; N-Methylaspartate; Pharmacology; Protein Overexpression; Reporting; Research; Research Personnel; Resources; Safety; Source; Transcript; United States National Institutes of Health; conditioned fear

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period, we found that the n. accumbens does not seemed to be involved in learning about safety cues, the brain brain-derived neurotrophic factor transcripts are differentially activated by fear learning, that NMDA antagonists into the basolateral, but not the medial nucleus of the amygdala block olfactory-mediated fear-potentiated startle, that overexpression of CREB in the amygdala facilitates fear learning in an ethologically relevant model of learning, and that gonadal steroids modulate our models of anxiety, but not conditioned fear.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 在报告期间，我们发现n。 a伏似乎没有参与学习安全提示，大脑脑衍生的神经营养因子转录本是通过恐惧学习而差异地激活的，即NMDA拮抗剂进入基底外侧，但没有杏仁核的内侧核的内侧核核酸内侧核。令人惊讶的是，杏仁核中Creb的过表达有助于在伦理上相关的学习模型中进行恐惧学习，而性腺类固醇可以调节我们的焦虑模型，但没有条件的恐惧。