PRIMATE AMYGDALA AND THE CONTROL OF VISUAL SEARCH OF EMOTIONAL STIMULI

灵长类杏仁核和情绪刺激视觉搜索的控制

• 批准号: 8357536
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357536
• 关键词: Amygdaloid structure; Animals; Cell Nucleus; Cells; Complex; Computers; Emotional; Emotional disorder; Equipment; Funding; Grant; Image; Injection of therapeutic agent; Monkeys; Muscimol; National Center for Research Resources; Nuclear; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Source; Training; United States National Institutes of Health; Visual attention; cost; design; effective intervention; emotional stimulus; instrument; sample fixation; social; visual search

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project examines the role of the primate amygdala in allocating visual attention to targets of emotional and social significance using reversible inactivation to separately manipulate two components of the amygdala complex; i.e. the centromedial and basolateral nuclear groups of the monkey amygdala. Since the funding of this project in September 2010, we have acquired a monkey and have instrumented this animal with a chamber that will allow access to the two nuclei. This animal has been also trained to fixate at a center point on a computer screen and visually explore images occurring at the fixation points. We have also acquired all the equipment to simultaneously record cell in the amygdala while injections of muscimol and bicuculine will either decrease or increase activity of the cells in the two amygdala nuclei. The results are expected to clarify the contribution of the amygdala to the acquisition of socially and emotionally relevant information-a critical prerequisite in designing a more effective intervention in socio-emotional disorders.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目研究了灵长类杏仁核在将视觉注意力分配给具有情感和社会意义的目标时的作用，使用可逆失活来分别操纵杏仁核复合体的两个组成部分；即猴子杏仁核的中心内侧和基底外侧核群。 自 2010 年 9 月资助该项目以来，我们获得了一只猴子，并为这只动物安装了一个可以进入两个细胞核的室。 这种动物还经过训练，可以注视计算机屏幕上的中心点，并在视觉上探索注视点处出现的图像。 我们还获得了同时记录杏仁核细胞的所有设备，同时注射蝇蕈醇和荷包牡丹碱将减少或增加两个杏仁核细胞的活性。研究结果有望阐明杏仁核对获取社会和情感相关信息的贡献——这是设计更有效的社会情感障碍干预措施的关键先决条件。