CONTINUITY OF THE LIMBIC CIRCUIT THROUGH THE BASAL GANGLIA

边缘回路通过基底神经节的连续性

• 批准号: 8172463
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172463
• 关键词: 1 year old; 3 year old; Age; Amygdaloid structure; Basal Ganglia; Behavioral; Birth; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Data; Development; Diffuse; Funding; Grant; Growth; Habits; Hippocampus (Brain); Incentives; Injection of therapeutic agent; Institution; Learning; Macaca mulatta; Mental Depression; Mental Health; Modeling; Nodal; Obsessive-Compulsive Disorder; Pathway interactions; Prefrontal Cortex; Research; Research Personnel; Resources; Schizophrenia; Source; Stress; System; Temporal Lobe; Time; Tracer; United States National Institutes of Health; addiction; age group; base; clinically relevant; infancy; postnatal; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project characterizes convergence of specific prefrontal cortex (PFC) inputs with the amygdala and temporal cortex in distinct striatal regions and investigates how this system undergoes refinement and reorganization consistent with postnatal milestones of behavioral development. We have currently ordered two rhesus monkeys (3-year-old and 1-year-old) to begin this project in January 2010 using MRI-guided injections of neuroanatomical tracers into the amygdala. We will (a) examine anatomical changes in cortex, striatum, amygdala and hippocampal pathways at the age of birth, 2-4 mo., 6 mo., 1 yr., and 3 years; (b) characterize the specific organization of cortical, amygdala, and hippocampal inputs to the striatum, with a particular focus on the refinement of diffuse projections and the convergence of focal projections; (c) will compare the models of convergent nodal regions across all age groups. Data obtained from such anatomical studies are clinically relevant because infancy through young adulthood is that critical time in which incentive-based learning forms the basis for behavioral guiding rules and the development of habits. Consistent with rapid behavioral development, the prefrontal cortex, amygdala, hippocampus and striatum undergo maturation during postnatal development. This time of developmental growth is associated with vulnerability to stress and the emergence of mental health problems including schizophrenia, depression, obsessive-compulsive disorders and addictions.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目描述了不同纹状体区域中特定前额叶皮层（PFC）输入与杏仁核和颞叶皮层的融合，并研究该系统如何进行与出生后行为发展里程碑一致的细化和重组。 目前，我们已订购两只恒河猴（3 岁和 1 岁），于 2010 年 1 月开始该项目，使用 MRI 引导将神经解剖示踪剂注射到杏仁核中。我们将 (a) 检查出生时、2-4 个月、6 个月、1 岁和 3 岁时皮质、纹状体、杏仁核和海马通路的解剖学变化； (b) 描述皮质、杏仁核和海马对纹状体输入的具体组织，特别关注弥散投影的细化和焦点投影的收敛； (c) 将比较所有年龄组的汇聚节点区域的模型。 从此类解剖学研究中获得的数据具有临床相关性，因为从婴儿期到成年早期是基于激励的学习形成行为指导规则和习惯发展基础的关键时期。与快速行为发育一致，前额皮质、杏仁核、海马体和纹状体在出生后发育过程中经历成熟。 这个发育成长时期与容易受到压力和精神健康问题（包括精神分裂症、抑郁症、强迫症和成瘾）的出现有关。