DEVELOPMENT OF MEDIAL TEMPORAL LOBE FUNCTIONS

内侧颞叶功能的发育

• 批准号: 8357420
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357420
• 关键词: Adolescent; Adult; Age; Animals; Area; Award; Brain; Data; Data Analyses; Development; Emotional; Fright; Funding; Grant; Hippocampus (Brain); Learning; Lesion; Medial; Mediating; Memory; Memory impairment; Monkeys; National Center for Research Resources; Neonatal; Positron-Emission Tomography; Primates; Principal Investigator; Protocols documentation; Research; Research Infrastructure; Resources; Short-Term Memory; Social Interaction; Source; System; Temporal Lobe; Testing; Training; United States National Institutes of Health; cost; infancy; memory process; memory recognition; relating to nervous system; social attachment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project investigates (a) the development of hippocampal and perirhinal cortex functions in monkeys, (b) the long-term consequences of early insult to these brain areas on the maturation of memory processes and social bonds, and (c) the anatomical reorganization of other brain systems resulting from these early lesions as compared to adult lesions. In the current year, we have trained animals with neonatal hippocampal (Neo-H) lesions and their controls in a spatial memory foraging task, contextual memory tasks, working memory tasks, and fear learning and its modulation. Neo-H lesions resulted in robust deficits in spatial learning and working memory, although the ability to use contextual memory and to learn and modulate fear was not altered. We also validated a PET imaging protocol to assess prefrontal functioning in Neo-H animals. To pursue the characterization of animals with neonatal perirhinal lesions (Neo-PRh), we assessed object and spatial recognition memory, social interactions and emotional reactivity in Neo-PRh animals and their controls as they were adolescent. The data analyzed so far show that, unlike Neo-H lesions, Neo-PRh lesions impaired incidental recognition memory at all ages and all delays tested. However, the recognition memory deficit in Group Neo-PRh was less in magnitude than that found after Adult-PRh lesions, suggesting that the neural substrate mediating item-specific memory processes is more widespread in early infancy. Data obtained in the other tasks are being currently analyzed. Renewal of this project for another 5 years was submitted in March 2010 and awarded in December 2010.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目研究（a）猴子海马和鼻周皮层功能的发育，（b）这些大脑区域的早期损伤对记忆过程和社会纽带成熟的长期影响，以及（c）大脑的解剖重组与成人病变相比，这些早期病变导致的其他大脑系统。 今年，我们对患有新生儿海马（Neo-H）病变的动物及其控制进行了空间记忆觅食任务、情境记忆任务、工作记忆任务以及恐惧学习及其调节的训练。 Neo-H 损伤导致空间学习和工作记忆的严重缺陷，尽管使用情境记忆以及学习和调节恐惧的能力没有改变。 我们还验证了 PET 成像方案，以评估 Neo-H 动物的前额叶功能。为了探究患有新生儿鼻周病变（Neo-PRh）的动物的特征，我们评估了 Neo-PRh 动物及其对照组在青少年时期的物体和空间识别记忆、社会互动和情绪反应性。 迄今为止分析的数据表明，与 Neo-H 损伤不同，Neo-PRh 损伤损害了所有年龄段和所有测试延迟的偶然识别记忆。然而，Neo-PRh 组的识别记忆缺陷程度比成人 PRh 损伤后发现的要小，这表明介导项目特异性记忆过程的神经基质在婴儿早期更为普遍。目前正在分析其他任务中获得的数据。该项目于 2010 年 3 月提交了续展 5 年的申请，并于 2010 年 12 月授予。