DEVELOPMENT OF MEDIAL TEMPORAL LOBE FUNCTIONS

内侧颞叶功能的发育

• 批准号: 8357420
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357420
• 关键词: Adolescent; Adult; Age; Animals; Area; Award; Brain; Data; Data Analyses; Development; Emotional; Fright; Funding; Grant; Hippocampus (Brain); Learning; Lesion; Medial; Mediating; Memory; Memory impairment; Monkeys; National Center for Research Resources; Neonatal; Positron-Emission Tomography; Primates; Principal Investigator; Protocols documentation; Research; Research Infrastructure; Resources; Short-Term Memory; Social Interaction; Source; System; Temporal Lobe; Testing; Training; United States National Institutes of Health; cost; infancy; memory process; memory recognition; relating to nervous system; social attachment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project investigates (a) the development of hippocampal and perirhinal cortex functions in monkeys, (b) the long-term consequences of early insult to these brain areas on the maturation of memory processes and social bonds, and (c) the anatomical reorganization of other brain systems resulting from these early lesions as compared to adult lesions. In the current year, we have trained animals with neonatal hippocampal (Neo-H) lesions and their controls in a spatial memory foraging task, contextual memory tasks, working memory tasks, and fear learning and its modulation. Neo-H lesions resulted in robust deficits in spatial learning and working memory, although the ability to use contextual memory and to learn and modulate fear was not altered. We also validated a PET imaging protocol to assess prefrontal functioning in Neo-H animals. To pursue the characterization of animals with neonatal perirhinal lesions (Neo-PRh), we assessed object and spatial recognition memory, social interactions and emotional reactivity in Neo-PRh animals and their controls as they were adolescent. The data analyzed so far show that, unlike Neo-H lesions, Neo-PRh lesions impaired incidental recognition memory at all ages and all delays tested. However, the recognition memory deficit in Group Neo-PRh was less in magnitude than that found after Adult-PRh lesions, suggesting that the neural substrate mediating item-specific memory processes is more widespread in early infancy. Data obtained in the other tasks are being currently analyzed. Renewal of this project for another 5 years was submitted in March 2010 and awarded in December 2010.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目调查了（a）猴子海马和周围皮层功能的发展，（b）早期对这些大脑区域的长期后果对记忆过程和社会纽带的成熟以及（c）与成人相比，其他早期病变导致其他早期系统的解剖学重组。 在当年，我们在空间记忆觅食任务，上下文记忆任务，工作记忆任务以及恐惧学习及其调制中训练了具有新生儿海马（NEO-H）病变及其控制的动物。 Neo-H病变导致空间学习和工作记忆的强大缺陷，尽管使用上下文记忆和学习和调节恐惧的能力并没有改变。 我们还验证了一种宠物成像方案，以评估NEO-H动物中的额叶功能。为了追求新生儿周围病变（NEO-PRH）的动物的特征，我们评估了对物体和空间识别记忆，社交相互作用和在青少年时的控制及其对照中的情感反应性。 到目前为止分析的数据表明，与NEO-H病变不同，NEO-PRH病变在所有年龄段的偶然识别记忆和所有延迟都损害了偶然的识别记忆。然而，NEO-PRH组的识别记忆不足的幅度要比成人PRH病变后发现的识别记忆不足，这表明神经底物介导特异性的记忆过程在婴儿早期期更为广泛。当前正在分析其他任务中获得的数据。该项目续签了5年，于2010年3月提交，并于2010年12月授予。