NEURAL SUBSTRATES CROSS-MODAL INTEGRATION OF SOCIO-EMOTIONAL CUES: PET IMAGING

社会情感线索的跨模式整合的神经基质：PET 成像

• 批准号: 7958225
• 负责人: JOCELYNE H BACHEVALIER
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958225
• 关键词: Adult; Amygdaloid structure; Animals; Complex; Computer Retrieval of Information on Scientific Projects Database; Cues; Data; Emotional; Emotions; Equipment; Exhibits; Eye; Face; Funding; Grant; Image; Imaging Techniques; Informal Social Control; Institution; Lesion; Macaca mulatta; Monkeys; Neonatal; Pattern; Positron-Emission Tomography; Primates; Research; Research Personnel; Resources; Schedule; Social Behavior; Source; Stimulus; System; Testing; Training; United States National Institutes of Health; Visual; frontal lobe; relating to nervous system; skills; social; sound; visual search; vocalization; Adult; Amygdaloid structure; Animals; Complex; Computer Retrieval of Information on Scientific Projects Database; Cues; Data; Emotional; Emotions; Equipment; Exhibits; Eye; Face; Funding; Grant; Image; Imaging Techniques; Informal Social Control; Institution; Lesion; Macaca mulatta; Monkeys; Neonatal; Pattern; Positron-Emission Tomography; Primates; Research; Research Personnel; Resources; Schedule; Social Behavior; Source; Stimulus; System; Testing; Training; United States National Institutes of Health; Visual; frontal lobe; relating to nervous system; skills; social; sound; visual search; vocalization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project combines eye-tracking and PET imaging techniques with a preferential looking task in rhesus macaques to assess the neural substrates underlying cross-modal integration of socially salient cues, a skill thought to be critical in self-regulation of social behavior. We have purchased all equipment, acquired all of the monkey face stimuli and sound vocalizations, and set-up all the equipment for the recording of the visual search patterns while the animals are passively viewing congruent (vocalization corresponding to facial emotions) and incongruent stimuli (vocalization not corresponding to facial emotions). Pilot testing has been completed on two normal adult monkeys and their data replicate previous findings such that normally developing monkeys exhibit an innate ability to integrate the audio and visual components of complex social cues. Using these criteria, we have now begun to test the experimental animals with neonatal lesions of the amygdala and orbital frontal cortex and the sham-operated controls. During the current year, we have also purchased the eye-tracking system and are currently training 6 monkeys on the paradigm. Initial tests indicate that animals rapidly habituate to stimuli presentation. We made significant adjustment in the schedule of stimuli presentation and inclusion of additional stimuli to reduce habituation during the 25 minute testing period required for PET imaging. The first subject will be ready for imaging trials during the coming year.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目将眼神跟踪和宠物成像技术与恒河猕猴中的优先外观任务相结合，以评估社会显着性线索的跨模式整合的神经基质，这一技能被认为对社会行为的自我调节至关重要。 我们已经购买了所有设备，购买了所有猴子面部的刺激和声音发声，并为录制视觉搜索模式的所有设备设置了动物，而动物正在被动地观看一致性（与面部情绪相对应的声音）和不一致的刺激（发声不与面部情绪相对应）。 试点测试已经完成了两只普通的成年猴子，他们的数据复制了以前的发现，即通常开发的猴子具有与众不同的能力，可以整合复杂社交提示的音频和视觉组成部分。使用这些标准，我们现在开始用杏仁核和轨道额叶皮层的新生儿病变和假手术对照来测试实验动物。 在本年度，我们还购买了引人注目的系统，目前正在范式上训练6只猴子。 初始测试表明动物迅速习惯于刺激表现。 我们对刺激表现的时间表进行了重大调整，并包括额外的刺激，以减少PET成像所需的25分钟测试期间的习惯。第一个主题将准备好在来年进行成像试验。