Perinatal risk factors and genetic susceptibility for childhood psychopathology

儿童精神病理学的围产期危险因素和遗传易感性

基本信息

批准号：
7532184
负责人：
Yoko Nomura
金额：
$ 17.66万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-18 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7532184
关键词：
Accounting Adult Affect Age Alcohol or Other Drugs use Amniocentesis Anxiety Anxiety Disorders Attention deficit hyperactivity disorder Behavior Behavioral Biological Birth Birth Records Birth Weight Child Child Development Childhood Clinical Cognitive deficits Collection Communities Data Data Collection Databases Development Diagnostic Discipline Disease Disease remission Disruptive Behavior Disorder Distal Drops Educational process of instructing Educational workshop Emotional Enrollment Environment Epidemiologic Studies Epigenetic Process Etiology Event Exhibits Family Follow-Up Studies Fright Future Generalized Anxiety Disorder Genetic Genetic Predisposition to Disease Genetic Risk Goals Heritability Hyperactive behavior Impairment Incidence Infant Infant Mortality Intervention Interview K-Series Research Career Programs Learning Length Longevity Longitudinal Studies Low Birth Weight Infant Measures Mediator of activation protein Medical Records Medicine Mental Depression Mental Health Mental disorders Mentored Research Scientist Development Award Mentors Methods Modeling Monitor Morbidity - disease rate Nature Neonatal Intensive Care Neonatal Intensive Care Units Neonatal Mortality New England Outcome Panic Disorder Pathway interactions Perinatal Perinatal Epidemiology Pregnancy Pregnancy Outcome Premature Birth Principal Investigator Problem behavior Psychiatry Psychopathology Psychosocial Stress Public Health Purpose Range Rate Recording of previous events Recurrence Reporting Research Research Infrastructure Research Methodology Research Personnel Research Training Risk Risk Factors Sampling Schools Scientist Series Social Phobia Societies Structure Survivors Symptoms Temperament Testing Training Training Activity Training Programs Traumatic Stress Disorders Week Work base cohort cost early childhood epidemiological model experience fetal functional disability genetic risk factor high school improved in utero inattention modifiable risk mortality multidisciplinary outcome forecast prenatal prenatal risk factor programs psychogenetics psychologic social statistics

项目摘要

DESCRIPTION (provided by applicant): A notable recent advance in psychiatry is the recognition that mental health problems can originate in-utero. Research in developmental psychopathology has shown that preterm birth is associated with a 2- to 3-fold increased risk of both disruptive behavior and anxiety disorders. However, no prior studies have examined why preterm birth is associated with a wide range of childhood disorders. Furthermore, few studies have integrated models based on research in perinatal epidemiology and psychiatric genetics to understand the trajectory of developmental psychopathology. The purpose of this Mentored Research Scientist Development Award (K01) is to support the development of the candidate to become an independent scientist whose work will focus on the impact of modifiable prenatal predictors on mental illness, taking into account genetic influences. To achieve this goal, the candidate's multidisciplinary group of mentors will teach her specific methods for studying fetal/child development and psychiatric genetics, and guide her selection of coursework. For the candidate successfully integrate these disparate scientific disciplines, the team of mentors will actively monitor and review the candidate's progress. The research plan was significantly refined and simplified, and proposes a program of research comprised of two related studies: 1) a longitudinal epidemiologic study of 2,022 children who were enrolled in the National Collaborative Perinatal Study - New England and followed into adulthood and 2) a longitudinal study of 225 children at high and low risk for Attention Deficit Hyperactivity Disorder. Two competing hypotheses will be tested: (1) that different causes of preterm birth independently influence the risk of disruptive behavior and anxiety disorders; and (2) that preterm birth, regardless of its cause, interacts with genetic susceptibility to directly increase the risk for each disorder. In this revised application, genetic and epigenetic training at Jackson Lab is proposed in a place of the additional longitudinal statistics workshop. As a part of the training, the candidate will conduct retrospective data collection to gather supplemental information on the early developmental environment during pregnancy while maximizing the infrastructure available in the second study. This research has significant public health implications in helping to elucidate the developmental, biological, and genetic pathways through which childhood disorders develop. Subsequent identification of very early modifiable risk factors for childhood disorders will create new possibilities for earlier and more effective interventions. This may help relieve the burden in families with young children exhibiting psychopathology by informing new treatment approaches for young children. Together, this research and training program will effect the candidate's transition to independence as an investigator and will contribute greatly to our understanding of modifiable risk factors for disruptive behavior and anxiety disorders for planning and testing future interventions.

描述（由申请人提供）：精神病学最近的一个显着进展是认识到心理健康问题可能起源于子宫内。发展精神病理学研究表明，早产会使破坏性行为和焦虑症的风险增加 2 至 3 倍。然而，之前没有研究探讨为什么早产与多种儿童期疾病相关。此外，很少有研究整合基于围产期流行病学和精神遗传学研究的模型来了解发育精神病理学的轨迹。指导研究科学家发展奖（K01）的目的是支持候选人发展成为一名独立科学家，其工作重点是研究可修改的产前预测因素对精神疾病的影响，同时考虑到遗传影响。为了实现这一目标，候选人的多学科导师小组将教她研究胎儿/儿童发育和精神遗传学的具体方法，并指导她选择课程。为了使候选人成功整合这些不同的科学学科，导师团队将积极监控和审查候选人的进展。该研究计划经过大幅改进和简化，提出了一项由两项相关研究组成的研究计划：1) 对参加新英格兰国家围产期合作研究并跟踪至成年的 2,022 名儿童进行纵向流行病学研究，2)对 225 名注意力缺陷多动障碍高风险和低风险儿童进行的纵向研究。将测试两个相互竞争的假设：（1）早产的不同原因独立影响破坏性行为和焦虑症的风险； (2) 早产，无论其原因如何，都会与遗传易感性相互作用，直接增加每种疾病的风险。在这个修订后的应用程序中，建议在杰克逊实验室进行遗传和表观遗传培训，以代替额外的纵向统计研讨会。作为培训的一部分，候选人将进行回顾性数据收集，以收集有关怀孕期间早期发育环境的补充信息，同时最大限度地利用第二项研究中可用的基础设施。这项研究对于帮助阐明儿童疾病发生的发育、生物学和遗传途径具有重要的公共卫生意义。随后识别儿童疾病的早期可改变危险因素将为更早、更有效的干预措施创造新的可能性。通过为幼儿提供新的治疗方法，这可能有助于减轻有表现出精神病理学幼儿的家庭的负担。总之，这项研究和培训计划将影响候选人向独立调查员的过渡，并将极大地有助于我们了解破坏性行为和焦虑症的可改变风险因素，以规划和测试未来的干预措施。