The Evolutionary Basis of the Developmental Course and Etiologies of Anxiety and Disruptive Behaviors during Early Adolescence

青春期早期焦虑和破坏性行为的发展过程和病因的进化基础

• 批准号: 10737103
• 负责人: Yoko Nomura
• 金额: $ 78.07万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-17 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737103
• 关键词: Acceleration; Adolescence; Adolescent; Age; Aggressive behavior; Amygdaloid structure; Anxiety; Area; Back; Behavior; Behavioral; Behavioral Symptoms; Biological; Birth; Brain; Buffers; COVID-19 pandemic; Child; Child Rearing; Childhood; Clinical; Cluster Analysis; Complement; Data Collection; Data Set; Development; Developmental Course; Diagnostic; Diffusion; Disease; Disruptive Behavior Disorder; Emotional; Environment; Etiology; Exposure to; Face; Family; Fright; Goals; Growth; Hair; Hippocampus; Individual; Individual Differences; Intervention; Interview; Life; Link; Measurable; Measures; Mediating; Mental Depression; Mental Health; Minority; Modeling; Mothers; Multimodal Imaging; National Institute of Mental Health; Natural Disasters; Natural experiment; Nature; Negative Valence; New York; Organ; Outcome; Participant; Phenotype; Population; Positioning Attribute; Pregnancy; Pregnant Women; Preparation; Protocols documentation; Psychopathology; Psychosocial Stress; Puberty; Quasi-experiment; Race; Random Allocation; Randomized; Regulation; Research Domain Criteria; Rest; Risk; Role; Sampling; Sex Differences; Signal Transduction; Source; Specimen; Stress; Structure; Surface; Symptoms; System; Testing; Thick; Time; United States National Institutes of Health; Work; behavior measurement; behavioral outcome; behavioral phenotyping; boys; childhood adversity; cognitive control; cohort; comorbidity; comparison control; coronavirus disease; early adolescence; early onset; fetal; fetal programming; follow up assessment; girls; gray matter; hazard; high risk; in utero; indexing; longitudinal analysis; low socioeconomic status; neural; neuroadaptation; neurobehavior; neurobehavioral; neuroimaging; neuromechanism; offspring; pandemic disease; pandemic impact; pandemic stress; postnatal; predictive modeling; preempt; prenatal; prenatal exposure; prenatal influence; prenatal stress; prospective; psychosocial; public health relevance; random forest; rate of change; recruit; repository; response; sex; sexual dimorphism; socioeconomics; stressor; substance use; symptomatology; white matter

Summary/Abstract: Accumulating evidence, including our own, indicates that in utero exposure to psychosocial stress is associated with risks for elevated anxiety (ANX) and disruptive behavior (DB) symptomatology. In this application, we will build on our existing birth cohort of children exposed and unexposed to Superstorm Sandy (SS) in utero. SS randomly “assigned” stressful conditions to pregnant women and their offspring in our cohort, giving us a unique opportunity to conduct a quasi-experiment of in utero stress. Using our deeply phenotyped cohort, we propose to investigate whether in utero SS exposure modulates the impact of the postnatal stressful environment, either amplifying (double-hit acceleration model) or shielding (stress inoculation model) the effects of postnatal stress on ANX and DB symptomatology. We will continue to measure different types of postnatal stress (normative, poor parenting, and COVID-related) to examine if magnitude, nature, timing and duration of the postnatal stressors influences the direction and impact on such symptomatology. As well as the DSM-based diagnostic outcomes, we will utilize the NIMH RDoC and focus on Negative Valence and Cognitive Control Systems (NVS/CCS), which will enable a transdiagnostic perspective of pre- and postnatal stress-related changes in behavior and the brain. Following our prior work, we will also examine sex-specific manifestations of the behavioral phenotypes (more internalizing problems in girls and more externalizing in boys) and explore the moderating role of SES when intersecting with individual differences in behaviors. As the brain is the central modulatory organ of stress/adaptation and regulation, we will use neuroimaging to assess changes in brain structure, function, and connectivity in limbic-frontal circuitry during early pre- and post-puberty, using a subsample of our cohort. Our cohort was followed from in utero, with completed follow-up assessments (neurobehavioral, clinical, and biological specimens), which will continue as they enter pre/puberty (ages 9-13), a time of peak risks for such problems and sex-dimorphism. Specifically, we will: 1) examine the effects of SS-related stress and the postnatal psychosocial environment on trajectories of clinical and adaptive neurobehaviors; 2) study the impact of prenatal SS stress and postnatal stress on NVS/CCS brain outcomes (structure and function) and evaluate the extent to which NVS/CCS structural changes mediate between prenatal SS-exposure and child anxiety and DB symptoms; and 3) develop predictive models for NVS/CCS outcomes in early adolescence based on biological and behavioral measures obtained in utero and/or the first decade of the child’s life. As pre/puberty is an important period of developmental transition and heightened risk for ANX and DB, we will build on our unique repository of both clinical and stored hair samples and continue to chart children’s neurobehavioral development and risk for psychopathology through ages 9-13. Together with the inclusion of neuroimaging to investigate neural mechanisms centered on the NVS/CCS and using tasks from the ABCD study, our study is uniquely positioned to elucidate the mechanisms of fetal programing and threat sensitivity in the NVS/SSV that modulate the risks for anxiety and reactive aggression.

摘要/摘要：越来越多的证据（包括我们自己的证据）表明，在子宫内暴露于社会心理 压力与焦虑升高 (ANX) 和破坏性行为 (DB) 症状风险相关。 在应用程序中，我们将以暴露于和未暴露于超级风暴桑迪 (SS) 的现有儿童出生队列为基础 SS 在我们的队列中随机向孕妇及其后代“分配”压力条件，从而给予 我们利用我们的深度表型队列进行了子宫内压力的准实验。 提议调查子宫内 SS 暴露是否调节产后压力环境的影响， 放大（双击加速模型）或屏蔽（应激接种模型）产后的影响 对 ANX 和 DB 症状的压力 我们将继续测量不同类型的产后压力（正常的、 不良养育方式以及与新冠病毒相关的），以检查产后压力源的强度、性质、时间和持续时间 影响这种症状的方向和影响以及基于 DSM 的诊断结果。 将利用 NIMH RDoC 并专注于负价和认知控制系统 (NVS/CCS)，这将 能够对产前和产后压力相关的行为和大脑变化提供跨诊断视角。 继我们之前的工作之后，我们还将检查行为表型的性别特异性表现（更多 女孩的问题内在化，男孩的问题更外化），并探讨社会经济地位在以下情况下的调节作用： 由于大脑是行为的中枢调节器官。 压力/适应和调节，我们将使用神经影像学来评估大脑结构、功能和调节的变化 使用我们队列的子样本在青春期前和青春期后的边缘-额叶回路的连接性。 队列从子宫内开始进行随访，并完成随访评估（神经行为、临床和生物学） 标本），这种情况将持续到他们进入青春期前/青春期（9-13岁），这是此类问题风险最高的时​​期， 具体来说，我们将：1）检查 SS 相关压力和产后心理社会的影响。 环境对临床和适应性神经行为轨迹的影响；2) 研究产前 SS 应激和 产后应激对 NVS/CCS 大脑结果（结构和功能）的影响，并评估 NVS/CCS 的程度 产前 SS 暴露与儿童焦虑和 DB 症状之间存在结构变化；3) 发生； 基于生物学和行为测量的青春期早期 NVS/CCS 结果的预测模型 在子宫内和/或孩子生命的前十年获得的，因为青春期前/青春期是发育的重要时期。 ANX 和 DB 的过渡和人员风险，我们将建立在我们独特的临床和存储存储库的基础上 头发样本，并通过以下方式继续绘制儿童的神经行为发育和精神病理学风险图： 年龄 9-13 岁，并纳入神经影像学以研究以 NVS/CCS 并使用 ABCD 研究中的任务，我们的研究具有独特的定位，可以阐明 NVS/SSV 中的胎儿编程和威胁敏感性可调节焦虑和反应性攻击的风险。