THE IDENTIFICATION OF PROTEIN-PROTEIN INTERACTION DOMAINS BY FRET

通过 FRET 鉴定蛋白质-蛋白质相互作用域

• 批准号: 7957801
• 负责人: ERIC MULLER
• 金额: $ 3.56万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957801
• 关键词: Biology; Computer Retrieval of Information on Scientific Projects Database; Fluorescence Resonance Energy Transfer; Funding; Fungal Genome; Grant; Institution; Methods; Protein Binding; Protein Binding Domain; Research; Research Personnel; Resources; Source; Tertiary Protein Structure; United States National Institutes of Health; base; protein protein interaction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Methods that identify protein binding partners are crucial to understanding the tapestry of protein-protein interactions. We will develop a FRET-based method to screen for domains of proteins that form stable contacts.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 识别蛋白质结合伴侣的方法对于理解蛋白质-蛋白质相互作用的织锦至关重要。我们将开发一种基于 FRET 的方法来筛选形成稳定接触的蛋白质结构域。