ULTRA-MICRO OXYGEN SENSOR DEVELOPMENT

超微氧传感器开发

• 批准号: 7953834
• 负责人: PETER JS SMITH
• 金额: $ 1.12万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953834
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Detection; Development; Funding; Grant; Hand; Institution; Manuals; Metabolism; Microelectrodes; Oxygen; Positioning Attribute; Production; Reporting; Research; Research Personnel; Resources; Signal Transduction; Source; Techniques; United States National Institutes of Health; improved; meetings; new technology; sensor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The resource has witnessed an increasing demand for applications targeting metabolism. To facilitate this we have developed several new technologies or integrated others to allow the study of cellular metabolism through several approaches. A number of these are reported on elsewhere. A key technique has been the application of self-referencing microsensors which to date have been constructed by hand (see SPID 0047) and with variable results. Although our efficiency here has greatly improved, manual production of amperometric sensors remains a bottleneck. To circumvent this we need to incorporate less variability in the construction, better define our optimal conditions and ultimately incorporate some form of automated or semi automated production. Overall we need to be in the position to supply microelectrodes meeting the exacting requirements of a non-invasive modulation technique for signal detection.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该资源见证了针对新陈代谢的应用程序的需求不断增加。 为了促进这一点，我们开发了几种新技术或集成了其他技术，以便通过多种方法研究细胞代谢。 其中一些在其他地方有报道。 一项关键技术是自参考微传感器的应用，迄今为止，该传感器是手工构建的（参见 SPID 0047）并具有可变的结果。 尽管我们的效率已经大大提高，但电流传感器的手动生产仍然是一个瓶颈。为了避免这种情况，我们需要在构造中减少可变性，更好地定义我们的最佳条件，并最终采用某种形式的自动化或半自动化生产。 总的来说，我们需要能够提供满足信号检测非侵入式调制技术严格要求的微电极。