NUTRIENT RESTRICTION-PLACENTAL AND FETAL BRAIN AND RENAL OUTCOMES AND MECHANISMS

营养限制——胎盘和胎儿的大脑和肾脏的结果和机制

• 批准号: 8172674
• 负责人: PETER W. NATHANIELSZ
• 金额: $ 10.23万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172674
• 关键词: Address; Adult; Apoptosis; Brain; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diabetes Mellitus; Diet; Eating; Elderly; Fetal Development; Funding; Goals; Grant; Growth; Growth and Development function; Health; Hypertension; Institution; Kidney; Life; Life Style; Morbidity - disease rate; Mothers; National Children' s Study; Nutrient; Obesity; Organ; Organism; Outcome; Papio; Perinatal Exposure; Placenta; Pregnancy; Research; Research Personnel; Resources; Rodent; Secondary to; Sheep; Source; Staging; System; Time; United States National Institutes of Health; Uterus; angiogenesis; detection of nutrient; experience; feeding; fetal; in utero; insight; maternal nutrient restriction; neonatal death; nephrogenesis; nonhuman primate; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sub-optimal fetal organ growth and development are major problems associated with increased neonatal death and long-term morbidity. Underlying mechanisms are poorly understood. Whilst primary causes are diverse, poor fetal development is generally secondary to fetal nutrient restriction. Rodent and sheep studies provide insight but parallel nonhuman primate data are minimal. The overall P01 goal is to study effects of global maternal nutrient restriction: restricted mothers eat 70% feed eaten by ad lib controls (CTR). We hypothesize that exposure of fetal baboons to nutrient restriction adversely impacts growth and key cellular processes in placenta, fetal brain and kidney. We hypothesize: 30% global maternal nutrient restriction 1: impairs growth; 2: impairs angiogenesis; 3: impacts the IGF system; 4: alters cellular nutrient sensing; 5. influences programmed cell death, in a fetal sex and developmental stage specific manner. The three projects are: Project 1  Nutrient Restriction: Baboon Placental Growth and Function; Project 2  Nutrient Restriction: Fetal Baboon Brain Development; Project 3  Nutrient Restriction: Fetal Baboon Renal Development. We use a unique combination of approaches to evaluate maternal nutrient effects on development of placenta and fetal brain and kidney, key organs for adult health. This P01 addresses National Children's Study goals. The mammalian organism passes more milestones during in utero development than any other time of life. Sub-optimal conditions in utero alter placental function and brain and kidney development. Our studies will help determine mechanisms by which conditions experienced in the womb predispose to high blood pressure, obesity and diabetes in later life. Clinicians will use the information to understand optimal life style and diet in pregnancy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 优化的胎儿器官生长和发育是与新生儿死亡和长期发病率增加有关的主要问题。基本机制知之甚少。尽管主要原因是多种原因，但胎儿发育不良通常是胎儿营养限制的继发性。啮齿动物和绵羊研究提供了洞察力，但平行的非人类灵长类动物数据最少。 总体P01目标是研究全球孕产妇限制的影响：受限制的母亲吃了由AD LIB控制（CTR）食用的70％饲料。我们假设胎儿​​狒狒暴露于营养限制会对胎盘，胎儿脑和肾脏的生长和关键细胞过程产生不利影响。我们假设：30％的全球母体营养限制1：损害增长； 2：损害血管生成； 3：影响IGF系统； 4：改变细胞营养感应； 5。以胎儿性别和发育阶段的特定方式影响程序性细胞死亡。这三个项目是：项目1营养限制：狒狒胎盘生长和功能；项目2营养限制：胎儿狒狒脑发育；项目3营养限制：胎儿狒狒肾脏发育。 我们使用独特的方法组合来评估孕产妇营养对胎盘和胎儿脑和肾脏发育的影响，这是成人健康的关键器官。该P01解决了国家儿童学习目标。 在子宫内发育过程中，哺乳动物的生物比其他任何时期都超过了里程碑。子宫内最佳条件改变了胎盘功能，大脑和肾脏发育。我们的研究将有助于确定子宫中经历的条件在晚年的高血压，肥胖症和糖尿病中的机制。 临床医生将使用这些信息来了解怀孕的最佳生活方式和饮食。