HEALTHY FAT (DAG)

健康脂肪 (DAG)

• 批准号: 7951349
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 0.18万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951349
• 关键词: Age-Years; Blinded; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Diet; Fatty acid glycerol esters; Funding; Grant; Institution; Parents; Participant; Randomized; Research; Research Personnel; Resources; Saturated Fatty Acids; Source; Testing; Trans Fats; Triglycerides; United States National Institutes of Health; Woman; feeding; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is about the search for the perfect fat, i.e. one that is trans fat-free but low is in saturated fatty acids. The PI proposes that a palm DAG may be an excellent choice. The hypothesis is that the modified fat (either palm DAG or palm kernel DAG), compared to the parent fat will result in a higher HDL-C, lower LDL-C, and lower LDL-C/HDL-C ratio, as well as potentially lower TG levels. A diet of 15 g/day of the palm or palm kernel DAG fat will be tested against the parent, unmodified palm or palm kernel fat. The study will be a randomized, 2-period, blinded cross-over design. A control background diet will be used throughout the feeding periods. Participants will include healthy men and women, 30-60 years of age, with moderately elevated LDL-C (120-175 mg/dL) and with HDL-C of 30-50 mg/dL and triglycerides of 120-350 mg/dL.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该提案旨在寻找完美的脂肪，即不含反式脂肪但饱和脂肪酸含量较低的脂肪。 PI 认为 Palm DAG 可能是一个很好的选择。 假设是，与母体脂肪相比，改性脂肪（棕榈 DAG 或棕榈仁 DAG）将导致较高的 HDL-C、较低的 LDL-C 和较低的 LDL-C/HDL-C 比率，以及可能会降低 TG 水平。每天 15 克的棕榈或棕榈仁 DAG 脂肪的饮食将与母体、未改性的棕榈或棕榈仁脂肪进行测试。 该研究将采用随机、两阶段、盲法交叉设计。在整个喂养期间将使用对照背景饮食。参与者将包括 30-60 岁的健康男性和女性，LDL-C 中度升高（120-175 mg/dL），HDL-C 为 30-50 mg/dL，甘油三酯为 120-350 mg/dL 。