BOLD (BEEF IN AN OPTIMAL LEAN DIET) EFFECTS ON METABOLIC SYNDROME BOLD-X

BOLD（最佳瘦肉饮食中的牛肉）对代谢综合征的影响 BOLD-X

• 批准号: 7951347
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 3.65万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951347
• 关键词: Blood Pressure; Body Weight decreased; Calories; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diet; Dietitian; Energy Intake; Funding; Goals; Grant; Human; Individual; Institution; Kinesiology; Metabolic syndrome; Modification; Monitor; Nutrient; Pamphlets; Participant; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Physical activity; Proteins; Recommendation; Research; Research Personnel; Resources; Risk Factors; Source; Training; Triglycerides; United States National Institutes of Health; Upper arm; beef; design; energy balance; feeding; fruits and vegetables; meetings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phase I) of this study was a four-week controlled, three parallel arm feeding trial of individuals with metabolic syndrome to compare the effects of three diets designed to meet nutrient recommendations with the following modifications: (1) lean beef 5 oz/day (overall diet is 18% energy from protein) (2) lean beef 7 oz/day (28% energy from protein or "high protein"); and (3) a modified version of the Dietary Approaches to Stop Hypertention (DASH) diet (high in fruits/vegetables and dairy with nutrient profile compositionally similar to #1. In this phase II of the study the participants continue on their respective diets but with decreased energy intake and increased physical activity designed to achieve weight loss of 1-2 pounds/week over six weeks (approximately 500-1000 calories/day in negative energy balance). Physical activity will be gradually increased beginning in the last two weeks of Phase I. Subjects will be provided with a pedometer to monitor daily step counts with a goal of achieving 8,000-10,000 steps/day on 5 or more days of the week by the end of phase II. This level of activity would be consistent with a "a somewhat active to active" level. During phase II subjects will receive physical activity and dietary guidance via pamphlets and face-to-fact sessions with a professional trained in human movement science and a registered dietitian. The investigators hypothesize that weight loss will be similar across diets but the highest protein diet will leaded to increased improvements in CV risk factors such as blood pressure and triglycerides when compared to the other two diets.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的第一阶段）是对患有代谢综合征的个体进行为期 4 周的对照、三组平行喂养试验，以比较三种饮食的效果，这些饮食旨在满足营养建议，并进行以下修改：（1）瘦牛肉 5 盎司/天（总体饮食中 18% 的能量来自蛋白质） (2) 瘦牛肉 7 盎司/天（28% 的能量来自蛋白质或“高蛋白”）； (3) 预防高血压饮食方法 (DASH) 的改良版（富含水果/蔬菜和乳制品，其营养成分与#1 相似）。 在该研究的第二阶段中，参与者继续各自的饮食，但减少能量摄入并增加体力活动，旨在在六周内实现每周减重 1-2 磅（能量负平衡时每天约减少 500-1000 卡路里） ）。 从第一阶段的最后两周开始，体力活动将逐渐增加。将为受试者提供计步器来监测每日步数，目标是在一周内有 5 天或更多天达到每天 8,000-10,000 步第二阶段。 该活性水平将与“有点活性到活性”水平一致。 在第二阶段，受试者将通过小册子和接受过人体运动科学培训的专业人士和注册营养师的面对面课程接受身体活动和饮食指导。 研究人员假设，不同饮食的减肥效果相似，但与其他两种饮食相比，最高蛋白质饮食将导致血压和甘油三酯等心血管危险因素的改善。