EFFECTS OF MEAL OCCASION & PLANT STEROL MULTIPLE CVD RF IN MOD HYPERCHOLESTEROL

用餐场合的影响

• 批准号: 7625847
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 30.02万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625847
• 关键词: Affect; Apolipoproteins; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Consumption; Dose; Fatty Acids; Funding; Goals; Grant; Inflammatory; Institution; LDL Cholesterol Lipoproteins; Lipids; Lipoproteins; Phytosterols; Plasma; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health; cardiovascular disorder risk; day; drinking; hypercholesterolemia

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Goal: To evaluate the effects on multiple cardiovascular disease (CVD) risk factors, including plasma lipids, lipoproteins, apolipoproteins, pro-inflammatory markers and the fatty acid profile, when a plant-sterol supplemented mini-drink is consumed once a day at either breakfast or dinner at varying doses. Hypothesis: Consumption of a plant sterol supplemented (2 g/d) mini-drink once a day with breakfast or dinner will decrease total and LDL-cholesterol by at least ~5% and beneficially affect plasma lipids, lipoproteins, apolipoproteins, pro-inflammatory markers, and the fatty acid profile in healthy subjects with moderate hypercholesterolemia (LDL-cholesterol 110 mg/dL).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目标：评估每日一次补充植物甾醇的迷你饮料对多种心血管疾病 (CVD) 危险因素的影响，包括血浆脂质、脂蛋白、载脂蛋白、促炎标记物和脂肪酸谱。早餐或晚餐不同剂量。 假设：每天在早餐或晚餐时饮用一次补充植物甾醇（2 克/天）的迷你饮料，可使总胆固醇和低密度脂蛋白胆固醇降低至少约 5%，并对血浆脂质、脂蛋白、载脂蛋白、促炎物质产生有益影响标记物，以及患有中度高胆固醇血症（LDL-胆固醇 110 mg/dL）的健康受试者的脂肪酸谱。