THE EFFECTS OF PROCESSED TOMATOES ON ENDOTHELIUM AND PLATELET FUNCTION

加工番茄对内皮和血小板功能的影响

• 批准号: 7951332
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 3.24万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951332
• 关键词: Adult; Affect; Antioxidants; Attenuated; Biological Markers; Blood Platelets; Blood Pressure; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Consumption; Diet; Eating; Endothelium; Fatty acid glycerol esters; Funding; Goals; Grant; Human; Inflammatory; Institution; Intake; Lipids; Oxidative Stress; Plasma; Platelet aggregation; Process; Research; Research Personnel; Resources; Source; Tomatoes; United States National Institutes of Health; Woman; aryldialkylphosphatase; disorder risk; high standard; improved; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this study are: (1) to compare the effect of high vs. low intake of processed tomatoes for 6 weeks on biomarkers of endothelium and platelet function; (2) to determine if the effects of a high fat meal known to induce platelet aggregation and reduce vaso-reactivity in humans are influenced by the background intake of processed tomato consumption or if concurrent processed tomato consumption is necessary to attenuate the described affects of the standard high fat meal; (3) to investigate the effects of high vs low consumption of processed tomatoes on plasma lipid composition, oxidative stress, blood pressure and inflammatory status in humans; (4) to determine if the antioxidants in the processed tomatoes will increase the human paraoxonase activity and concentration. The investigators hypothesize that: (1) consuming processed tomatoes frequently/daily will favorably improve endothelium and platelet function disease-risk biomarker profiles in adult men and women compared to consuming no or relatively low amounts of processed tomatoes; (2) consuming processed tomatoes frequently/daily to produce a stable background intake of processed tomatoes compared to no/ low background intake of processed tomatoes will be required to attenuate vaso-constrictive and platelet aggregatory effects of a standard high fat meal. Consuming a background diet low in processed tomatoes will require a single serving of processed tomatoes to be eaten concurrently to attenuate the vaso-constrictive and platelet aggregatory effects of the meal; (3) consuming processed tomatoes frequently/daily will improve blood pressure, the plasma lipid profile, oxidative stress and inflammatory status.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目标是：（1）比较连续 6 周高与低摄入加工番茄对内皮和血小板功能生物标志物的影响； (2) 确定已知的高脂肪膳食对人体的诱导血小板聚集和降低血管反应性的影响是否受到加工番茄消费背景摄入量的影响，或者是否需要同时食用加工番茄来减弱所描述的影响。标准高脂肪餐； (3) 研究高与低食用加工番茄对人体血浆脂质成分、氧化应激、血压和炎症状态的影响； (4)确定加工后的番茄中的抗氧化剂是否会增加人体对氧磷酶的活性和浓度。 研究人员假设：（1）与不食用或相对少量加工番茄相比，经常/每天食用加工番茄将有利于改善成年男性和女性的内皮和血小板功能疾病风险生物标志物特征； (2) 与不摄入或低背景摄入加工番茄相比，需要经常/每天食用加工番茄以产生稳定的加工番茄背景摄入量，以减弱标准高脂肪膳食的血管收缩和血小板聚集效应。食用加工番茄含量较低的背景饮食将需要同时食用一份加工番茄，以减弱膳食的血管收缩和血小板聚集作用； (3) 经常/每天食用加工过的西红柿会改善血压、血脂、氧化应激和炎症状态。