Impact of Exposure to Perfluoroalkyl Substances on Weight Loss: A Pilot Study of Hispanic Children with Overweight/Obesity Participating in a Community-based Weight Loss Intervention Program

接触全氟烷基物质对减肥的影响：对参加社区减肥干预计划的超重/肥胖西班牙裔儿童的初步研究

• 批准号: 10724050
• 负责人: Michael S Bloom
• 金额: $ 15.89万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724050
• 关键词: Address; Adipocytes; Affect; Age; Analytical Chemistry; Biological Markers; Biological Monitoring; Biomedical Research; Biometry; Blood; Blood Pressure; Blood specimen; Body Weight; Body Weight decreased; Body fat; Body mass index; C-reactive protein; Calories; Cessation of life; Chemicals; Child; Cholesterol; Chronic Disease; Clinical; Communities; Complex; Data; Desire for food; Diastolic blood pressure; Disease; Distress; Energy Metabolism; Ensure; Environmental Risk Factor; Epidemiology; Etiology; Exercise Physiology; Exposure to; Family; Foundations; Funding; Future; Genetic; Glucose; Glycosylated hemoglobin A; Goals; Health; High Density Lipoproteins; High Prevalence; Hispanic; Hispanic Populations; Hormones; Hypertension; Individual; Insulin; Intervention; Investigation; Lipids; Lipoproteins; Low-Density Lipoproteins; Luteinizing Hormone; Measures; Metabolic; Metabolic syndrome; Metabolism; Not Hispanic or Latino; Obesity; Overweight; Parents; Participant; Pathway interactions; Physical activity; Physiology; Pilot Projects; Play; Poly-fluoroalkyl substances; Population; Positioning Attribute; Proliferating; Public Health; Research; Risk; Risk Factors; Role; Satiation; Serum; Testing; Triglycerides; Weight; Weight maintenance regimen; Youth; adult obesity; cardiometabolism; clinical biomarkers; cost effective; density; effective intervention; experience; fast food; healthy weight; improved; intervention program; lifestyle factors; liver function; modifiable risk; obesity in children; obesity prevention; obesity risk; obesogen; obesogenic; post intervention; premature; prospective; psychosocial; sex; sociodemographic factors; weight loss intervention

Child obesity is a public health crisis that disproportionately impacts Hispanic children. We propose a pilot study of associations between perfluoroalkyl substances (PFAS) with weight lost among overweight/obese Hispanic children who participated in a 10-week weight loss intervention. The focus will be on pre- vs. post-intervention differences in body weight, blood pressure and serum lipids associated with pre-intervention PFAS exposure. The results will have implications for identifying factors that modify weight loss in children, and will lay the groundwork for a more definitive and larger investigation to be supported by an R01 application. Our proposal addresses a critical research gap. Despite widespread exposure to PFAS among children, experimental evidence of obesogenic effects, and a growing body of epidemiologic results suggesting obesogenic effects, the impact of PFAS exposure on children’s weight loss has yet to be evaluated. Furthermore, no studies have focused on PFAS and weight loss in a Hispanic population, which experiences a greater obesity risk than non-Hispanic children. This proposal builds upon the Vidas Activas y Familias Saludables (VALE) study, a culturally-tailored 10-week community-based weight loss intervention, which significantly reduced children’s BMI, percent body fat, blood pressure and serum non-high density lipoproteins. We will measure 12 legacy and emerging PFAS in VALE study blood specimens previously collected before the weight loss intervention, as prospective predictors of the differences in body weight, blood pressure and serum lipids. We expect that pre-intervention PFAS will correlate to changes in weight loss, blood pressure and serum lipids. We will also estimate the prospective impact of simultaneous co-exposure to the mixture of 12 measured PFAS. Finally, we will explore cross-sectional associations between PFAS and previously measured serum biomarkers of metabolism, lipids, hormones and liver function in pre-intervention blood specimens. Ours will be the first investigation of PFAS exposure and children’s weight loss, and the first US study of PFAS and weight loss focused upon Hispanic youth. Successful completion of our project is ensured by the experience of the team, who implemented the parent VALE study, and have the necessary expertise in epidemiology, biostatistics, analytical chemistry and exercise physiology. The proposed pilot study is the first step in a long term strategy to advance understanding of how exposure to environmental factors, including PFAS, affect weight loss among children, to develop targeted interventions. These data will be used to develop an R01 application to support a larger, more definitive and mechanistic future study to address this important biomedical research gap regarding the obesogenic effects of PFAS on weight loss in children.

儿童肥胖是一种公共卫生危机，对西班牙裔儿童产生了不成比例的影响。我们提出了一项试点研究 超重/肥胖西班牙裔在全氟烷基物质（PFA）之间的关联 参加为期10周的减肥干预措施的孩子。重点将放在干预后与干预后 与干预前PFAS暴露有关的体重，血压和血清脂质的差异。 结果将对识别改变儿童体重减轻的因素有影响，并将 R01应用程序支持更确定和更大的投资的基础。 我们的建议解决了关键的研究差距。尽管儿童中PFA的广泛性暴露，但 肥胖作用的实验证据，以及越来越多的流行病学结果表明 肥胖作用，PFA暴露对儿童体重减轻的影响尚未评估。此外， 没有研究集中于西班牙裔人口中的PFA和体重减轻，这会经历更大的肥胖症 风险比非西班牙裔儿童。该建议建立在vidas activas y familias saludables（谷）研究的基础上， 一项经过文化制定的10周基于社区的减肥干预措施，大大减少了儿童 BMI，体内脂肪百分比，血压和血清非密度脂蛋白。 我们将在谷研究中测量12个遗产和新兴的PFA，以前在先前收集的血液标本 减肥干预措施，作为体重，血压和系列差异的前瞻性预测指标 脂质。我们期望干预前的PFA与体重减轻，血压和系列的变化有关 脂质。我们还将估计简单的共曝光对12个测量的混合物的前瞻性影响 PFA。最后，我们将探索PFA与先前测量的串行之间的横截面关联 在干预前的血液标本中，代谢，脂质，辣椒和肝功能的生物标志物。 我们的将是PFAS暴露和儿童减肥的首次投资，也是美国首次研究PFA 体重减轻集中在西班牙裔青年上。通过经验确保了成功完成我们项目的完成 在实施父谷研究的团队中，具有流行病学的必要专业知识， 生物统计学，分析化学和运动生理学。拟议的试点研究是长时间的第一步 术语策略，以提高对环境因素（包括PFA）如何影响体重的了解的术语策略 儿童的损失，制定有针对性的干预措施。这些数据将用于开发R01应用程序 支持更大，更确定和机械的未来研究，以解决这一重要的生物医学研究 关于PFA对儿童体重减轻的肥胖作用的缺口。