Impact of Exposure to Perfluoroalkyl Substances on Weight Loss: A Pilot Study of Hispanic Children with Overweight/Obesity Participating in a Community-based Weight Loss Intervention Program

接触全氟烷基物质对减肥的影响：对参加社区减肥干预计划的超重/肥胖西班牙裔儿童的初步研究

• 批准号: 10724050
• 负责人: Michael S Bloom
• 金额: $ 15.89万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724050
• 关键词: Address; Adipocytes; Affect; Age; Analytical Chemistry; Biological Markers; Biological Monitoring; Biomedical Research; Biometry; Blood; Blood Pressure; Blood specimen; Body Weight; Body Weight decreased; Body fat; Body mass index; C-reactive protein; Calories; Cessation of life; Chemicals; Child; Cholesterol; Chronic Disease; Clinical; Communities; Complex; Data; Desire for food; Diastolic blood pressure; Disease; Distress; Energy Metabolism; Ensure; Environmental Risk Factor; Epidemiology; Etiology; Exercise Physiology; Exposure to; Family; Foundations; Funding; Future; Genetic; Glucose; Glycosylated hemoglobin A; Goals; Health; High Density Lipoproteins; High Prevalence; Hispanic; Hispanic Populations; Hormones; Hypertension; Individual; Insulin; Intervention; Investigation; Lipids; Lipoproteins; Low-Density Lipoproteins; Luteinizing Hormone; Measures; Metabolic; Metabolic syndrome; Metabolism; Not Hispanic or Latino; Obesity; Overweight; Parents; Participant; Pathway interactions; Physical activity; Physiology; Pilot Projects; Play; Poly-fluoroalkyl substances; Population; Positioning Attribute; Proliferating; Public Health; Research; Risk; Risk Factors; Role; Satiation; Serum; Testing; Triglycerides; Weight; Weight maintenance regimen; Youth; adult obesity; cardiometabolism; clinical biomarkers; cost effective; density; effective intervention; experience; fast food; healthy weight; improved; intervention program; lifestyle factors; liver function; modifiable risk; obesity in children; obesity prevention; obesity risk; obesogen; obesogenic; post intervention; premature; prospective; psychosocial; sex; sociodemographic factors; weight loss intervention

Child obesity is a public health crisis that disproportionately impacts Hispanic children. We propose a pilot study of associations between perfluoroalkyl substances (PFAS) with weight lost among overweight/obese Hispanic children who participated in a 10-week weight loss intervention. The focus will be on pre- vs. post-intervention differences in body weight, blood pressure and serum lipids associated with pre-intervention PFAS exposure. The results will have implications for identifying factors that modify weight loss in children, and will lay the groundwork for a more definitive and larger investigation to be supported by an R01 application. Our proposal addresses a critical research gap. Despite widespread exposure to PFAS among children, experimental evidence of obesogenic effects, and a growing body of epidemiologic results suggesting obesogenic effects, the impact of PFAS exposure on children’s weight loss has yet to be evaluated. Furthermore, no studies have focused on PFAS and weight loss in a Hispanic population, which experiences a greater obesity risk than non-Hispanic children. This proposal builds upon the Vidas Activas y Familias Saludables (VALE) study, a culturally-tailored 10-week community-based weight loss intervention, which significantly reduced children’s BMI, percent body fat, blood pressure and serum non-high density lipoproteins. We will measure 12 legacy and emerging PFAS in VALE study blood specimens previously collected before the weight loss intervention, as prospective predictors of the differences in body weight, blood pressure and serum lipids. We expect that pre-intervention PFAS will correlate to changes in weight loss, blood pressure and serum lipids. We will also estimate the prospective impact of simultaneous co-exposure to the mixture of 12 measured PFAS. Finally, we will explore cross-sectional associations between PFAS and previously measured serum biomarkers of metabolism, lipids, hormones and liver function in pre-intervention blood specimens. Ours will be the first investigation of PFAS exposure and children’s weight loss, and the first US study of PFAS and weight loss focused upon Hispanic youth. Successful completion of our project is ensured by the experience of the team, who implemented the parent VALE study, and have the necessary expertise in epidemiology, biostatistics, analytical chemistry and exercise physiology. The proposed pilot study is the first step in a long term strategy to advance understanding of how exposure to environmental factors, including PFAS, affect weight loss among children, to develop targeted interventions. These data will be used to develop an R01 application to support a larger, more definitive and mechanistic future study to address this important biomedical research gap regarding the obesogenic effects of PFAS on weight loss in children.

儿童肥胖是一种公共卫生危机，对西班牙裔儿童的影响尤为严重。我们提出了一项试点研究。 全氟烷基物质 (PFAS) 与超重/肥胖西班牙裔体重减轻之间的关联 参加为期 10 周减肥干预的儿童 重点将放在干预前与干预后。 与干预前 PFAS 暴露相关的体重、血压和血脂差异。 研究结果将对确定改变儿童体重减轻的因素产生影响，并将奠定 为 R01 应用程序支持的更明确、更大规模的调查奠定基础。 尽管儿童普遍接触 PFAS，但我们的提案解决了一个关键的研究空白。 致肥胖效应的实验证据以及越来越多的流行病学结果表明 肥胖效应，PFAS 暴露对儿童体重减轻的影响尚未得到评估。 没有研究关注 PFAS 与西班牙裔人群减肥的关系，因为西班牙裔人群的肥胖程度更高 该提案基于 Vidas Activas y Familias Saludables (VALE) 研究， 根据文化量身定制的为期 10 周的社区减肥干预措施，显着降低了儿童的体重 BMI、体脂百分比、血压和血清非高密度脂蛋白。 我们将测量之前在 VALE 研究中收集的 12 种遗留和新兴 PFAS 血液样本 减肥干预，作为体重、血压和血清差异的前瞻性预测因素 我们预计干预前的 PFAS 将与体重减轻、血压和血清的变化相关。 我们还将估计同时暴露于 12 种测量的混合物的预期影响。 最后，我们将探讨 PFAS 与之前测量的血清之间的横向关联。 干预前血液样本中代谢、脂质、激素和肝功能的生物标志物。 我们的研究将是第一个关于 PFAS 暴露和儿童体重减轻的调查，也是美国第一个关于 PFAS 的研究 我们的经验确保了我们项目的成功完成。 执行母公司 VALE 研究并拥有流行病学必要专业知识的团队成员， 生物统计学、分析化学和运动生理学的初步研究是长期研究的第一步。 促进了解环境因素（包括 PFAS）暴露如何影响体重的术语策略 儿童损失，以制定有针对性的干预措施。这些数据将用于开发 R01 应用程序。 支持未来更大规模、更明确和机械化的研究来解决这一重要的生物医学研究 关于 PFAS 对儿童体重减轻的致肥作用的差距。