Racial Disparities Associated with Maternal Exposure to Environmental Endocrine Disrupting Compounds in a Southeastern U.S. Community

美国东南部社区中与母亲接触环境内分泌干扰化合物相关的种族差异

• 批准号: 10269022
• 负责人: Michael S Bloom
• 金额: $ 16.75万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-24 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10269022
• 关键词: Address; Affect; African American; Age; Analytical Chemistry; Archives; Benzophenones; Beverages; Biological Markers; Biomedical Research; Biometry; Birth; Blood specimen; Clinical; Clinical Data; Collaborations; Communities; Complex Mixtures; Confounding Factors (Epidemiology); Consent; Data; Development; Dimensions; Discipline of obstetrics; Discrimination; Education; Endocrine Disruptors; Endocrine disruption; Ensure; Environmental Pollutants; Epidemiology; Exhibits; Exposure to; Family; Fetal Development; Food; Foundations; Future; Gender; Gestational Age; Goals; Hormonal; Income; Infant; Investigation; Joints; Life Style; Low Birth Weight Infant; Maternal Exposure; Measures; Medical Records; Modeling; Mothers; National Institute of Environmental Health Sciences; Newborn Infant; Outcome; Parabens; Participant; Pharmaceutical Preparations; Phenols; Population; Positioning Attribute; Pregnancy; Pregnant Women; Premature Birth; Prospective cohort study; Psychosocial Stress; Questionnaires; Race; Recording of previous events; Reporting; Reproductive Endocrinology; Reproductive Health; Research; Risk Factors; Second Pregnancy Trimester; Source; South Carolina; Strategic Planning; Third Pregnancy Trimester; Ultrasonography; Umbilical Cord Blood; Urine; Work; adverse birth outcomes; androgenic; anogenital distance; bisphenol A; cohort; environmental agent; epidemiology study; experience; fetal; health disparity; high risk; in utero; innovation; modifiable risk; penis; perceived stress; personal care products; phthalates; pregnant; premature; prenatal exposure; racial disparity; sex; social health determinants; sociodemographics; study population; success; urinary

PROJECT SUMMARY Aims: We propose a prospective cohort study to examine fetal developmental effects from gestational exposure to endocrine disrupting environmental phenols (EPs) and phthalates (PHTs) in African American (AA) and white mothers in a southeastern U.S. obstetrical population. The focus will be on how associations of EPs with fetal developmental outcomes vary by race. We will also explore how co-exposure to both EPs and PHTs influence these associations. Significance: The proposed study will fundamentally advance our understanding of racial disparities in exposure to EPs and how these differences may contribute to reproductive health disparities between AAs and whites. We will also explore the joint effects of gestational co-exposure to a complex mixture of EPs and PHTs on fetal development. This study directly addresses significant gaps in our understanding the impact of highly prevalent EPs and PHTs on fetal development among AAs and lays the foundation for a more definitive future study of the effect of mixed endocrine disrupting exposures on reproductive health disparities. Innovation: The proposed study will be the 1st to leverage a cohort of AA and white mothers and their newborns, to directly assess health disparities in gestational exposure to a mixture of EPs and PHTs with fetal developmental outcomes. It will be one of few studies to assess the impact of mixed gestational exposure to EPs and PHTs and the 1st to capture these data in the southeastern U.S., where disparities in rates of prematurity and low birth weight between AAs and whites is the highest in the U.S. Preliminary Study: This proposal builds upon a prospective cohort study of 8 prevalent urinary PHTs that we previously measured and fetal development among AA and white mothers in Charleston, South Carolina. The results provide strong support for the approach outlined, especially in regard to differential effects by race. Approach: AA (n=152) and white (n=158) mother-infant pairs completed our study between 2011-2014. Participants provided urine and blood specimens during gestation and at delivery, had a detailed mid-gestation fetal ultrasound, completed a study questionnaire about exposure sources and consented to medical records access. We will measure 10 prevalent EPs in archived maternal urine and correlate the concentrations to birth outcomes, newborn anogenital distances and penis dimensions by mid-gestation ultrasound and at delivery. We will explore the impact of co-exposure to EPs and PHTs and how these results vary by race. Successful completion of our project is ensured by the experience of the team, who worked together to complete the previous project, and have the necessary expertise in obstetrics, reproductive endocrinology, analytic chemistry, epidemiology and biostatistical modeling. These data will be used to develop an R01 application to support a more comprehensive and mechanistic future study to address this important biomedical research gap regarding racially disparate developmental effects of fetal exposure to endocrine disrupting compounds.

项目概要 目的：我们提出一项前瞻性队列研究来检查妊娠期胎儿发育的影响 非裔美国人接触内分泌干扰环境酚 (EP) 和邻苯二甲酸盐 (PHT) (AA) 和美国东南部产科人群中的白人母亲。重点是协会如何 EP 与胎儿发育结果的关系因种族而异。我们还将探讨如何同时接触 EP 和 PHT 影响这些关联。 意义：拟议的研究将从根本上增进我们对种族差异的理解 EP 暴露以及这些差异如何导致 AA 之间的生殖健康差异 和白人。我们还将探讨妊娠期同时暴露于 EP 和 EP 的复杂混合物的联合影响。 PHT 对胎儿发育的影响。这项研究直接解决了我们对影响的理解方面的重大差距 AA 中非常普遍的 EP 和 PHT 对胎儿发育的影响，并为更明确的 未来研究混合内分泌干扰物暴露对生殖健康差异的影响。 创新：拟议的研究将是第一个利用 AA 和白人母亲及其她们的群体的研究 新生儿，直接评估妊娠期暴露于 EP 和 PHT 混合物与胎儿的健康差异 发展成果。这将是评估混合妊娠暴露影响的少数研究之一 EP 和 PHT 以及第一个在美国东南部捕获这些数据的国家，那里的比率存在差异 AA 族和白人之间的早产率和低出生体重率是美国最高的 初步研究：该提案以我们对 8 种常见尿路 PHT 进行的前瞻性队列研究为基础。 之前对南卡罗来纳州查尔斯顿的 AA 和白人母亲进行了测量和胎儿发育情况。这 结果为所概述的方法提供了强有力的支持，特别是在种族差异影响方面。 方法：AA (n=152) 和白人 (n=158) 母婴对在 2011 年至 2014 年期间完成了我们的研究。 参与者在妊娠期间和分娩时提供尿液和血液样本，并获得详细的妊娠中期情况 胎儿超声检查，完成有关暴露源的研究调查问卷并同意医疗记录 使用权。我们将测量存档的母体尿液中 10 种常见的 EP，并将其浓度与出生相关联 通过妊娠中期超声和分娩时的结果、新生儿肛门生殖器距离和阴茎尺寸。 我们将探讨同时接触 EP 和 PHT 的影响以及这些结果如何因种族而异。成功的 我们的项目的完成是由团队的经验保证的，他们共同努力完成了 以前的项目，并拥有产科、生殖内分泌学、分析学方面必要的专业知识 化学、流行病学和生物统计模型。这些数据将用于开发 R01 应用程序 支持更全面、更机械的未来研究来解决这一重要的生物医学研究 关于胎儿暴露于内分泌干扰化合物的种族差异发育影响的差距。