Racial Disparities Associated with Maternal Exposure to Environmental Endocrine Disrupting Compounds in a Southeastern U.S. Community

美国东南部社区中与母亲接触环境内分泌干扰化合物相关的种族差异

• 批准号: 10269022
• 负责人: Michael S Bloom
• 金额: $ 16.75万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-24 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10269022
• 关键词: Address; Affect; African American; Age; Analytical Chemistry; Archives; Benzophenones; Beverages; Biological Markers; Biomedical Research; Biometry; Birth; Blood specimen; Clinical; Clinical Data; Collaborations; Communities; Complex Mixtures; Confounding Factors (Epidemiology); Consent; Data; Development; Dimensions; Discipline of obstetrics; Discrimination; Education; Endocrine Disruptors; Endocrine disruption; Ensure; Environmental Pollutants; Epidemiology; Exhibits; Exposure to; Family; Fetal Development; Food; Foundations; Future; Gender; Gestational Age; Goals; Hormonal; Income; Infant; Investigation; Joints; Life Style; Low Birth Weight Infant; Maternal Exposure; Measures; Medical Records; Modeling; Mothers; National Institute of Environmental Health Sciences; Newborn Infant; Outcome; Parabens; Participant; Pharmaceutical Preparations; Phenols; Population; Positioning Attribute; Pregnancy; Pregnant Women; Premature Birth; Prospective cohort study; Psychosocial Stress; Questionnaires; Race; Recording of previous events; Reporting; Reproductive Endocrinology; Reproductive Health; Research; Risk Factors; Second Pregnancy Trimester; Source; South Carolina; Strategic Planning; Third Pregnancy Trimester; Ultrasonography; Umbilical Cord Blood; Urine; Work; adverse birth outcomes; androgenic; anogenital distance; bisphenol A; cohort; environmental agent; epidemiology study; experience; fetal; health disparity; high risk; in utero; innovation; modifiable risk; penis; perceived stress; personal care products; phthalates; pregnant; premature; prenatal exposure; racial disparity; sex; social health determinants; sociodemographics; study population; success; urinary

PROJECT SUMMARY Aims: We propose a prospective cohort study to examine fetal developmental effects from gestational exposure to endocrine disrupting environmental phenols (EPs) and phthalates (PHTs) in African American (AA) and white mothers in a southeastern U.S. obstetrical population. The focus will be on how associations of EPs with fetal developmental outcomes vary by race. We will also explore how co-exposure to both EPs and PHTs influence these associations. Significance: The proposed study will fundamentally advance our understanding of racial disparities in exposure to EPs and how these differences may contribute to reproductive health disparities between AAs and whites. We will also explore the joint effects of gestational co-exposure to a complex mixture of EPs and PHTs on fetal development. This study directly addresses significant gaps in our understanding the impact of highly prevalent EPs and PHTs on fetal development among AAs and lays the foundation for a more definitive future study of the effect of mixed endocrine disrupting exposures on reproductive health disparities. Innovation: The proposed study will be the 1st to leverage a cohort of AA and white mothers and their newborns, to directly assess health disparities in gestational exposure to a mixture of EPs and PHTs with fetal developmental outcomes. It will be one of few studies to assess the impact of mixed gestational exposure to EPs and PHTs and the 1st to capture these data in the southeastern U.S., where disparities in rates of prematurity and low birth weight between AAs and whites is the highest in the U.S. Preliminary Study: This proposal builds upon a prospective cohort study of 8 prevalent urinary PHTs that we previously measured and fetal development among AA and white mothers in Charleston, South Carolina. The results provide strong support for the approach outlined, especially in regard to differential effects by race. Approach: AA (n=152) and white (n=158) mother-infant pairs completed our study between 2011-2014. Participants provided urine and blood specimens during gestation and at delivery, had a detailed mid-gestation fetal ultrasound, completed a study questionnaire about exposure sources and consented to medical records access. We will measure 10 prevalent EPs in archived maternal urine and correlate the concentrations to birth outcomes, newborn anogenital distances and penis dimensions by mid-gestation ultrasound and at delivery. We will explore the impact of co-exposure to EPs and PHTs and how these results vary by race. Successful completion of our project is ensured by the experience of the team, who worked together to complete the previous project, and have the necessary expertise in obstetrics, reproductive endocrinology, analytic chemistry, epidemiology and biostatistical modeling. These data will be used to develop an R01 application to support a more comprehensive and mechanistic future study to address this important biomedical research gap regarding racially disparate developmental effects of fetal exposure to endocrine disrupting compounds.

项目摘要 目的：我们提出了一项前瞻性队列研究，以检查妊娠的胎儿发育效果 在非裔美国人中暴露于内分泌破坏环境酚（EPS）和邻苯二甲酸盐（PHT） （AA）和美国东南部妇产产的白人母亲。重点将放在联想如何 胎儿发育结果的EPS的不同之处在于种族。我们还将探讨如何共同暴露于EP和 PHT会影响这些关联。 意义：拟议的研究将从根本上提高我们对种族差异的理解 暴露于EPS以及这些差异如何导致AAS生殖健康差异 和白人。我们还将探索妊娠共同暴露于EPS的复杂混合物和 关于胎儿发育的PHT。这项研究直接解决了我们理解的重大差距 高度普遍的EP和PHT关于AAS的胎儿发育，并为更确定的基础奠定了基础 未来研究混合内分泌暴露对生殖健康差异的影响。 创新：拟议的研究将是第一个利用AA和白人母亲及其同类的研究 新生儿，直接评估妊娠暴露于EPS和PHT与胎儿混合的健康差异 发展结果。这将是评估混合妊娠暴露对的少数研究之一 EPS和PHT以及第一个在美国东南部捕获这些数据的第一名 AAS和白人之间的早产和低出生体重在美国最高 初步研究：该提案建立在对我们的8个流行尿道PHT的前瞻性队列研究的基础上 先前在南卡罗来纳州查尔斯顿的AA和白人母亲之间进行了测量和胎儿发育。这 结果为概述的方法提供了强有力的支持，尤其是关于种族的差异效应。 方法：AA（n = 152）和白色（n = 158）对母亲对完成了我们的研究2011 - 2014年之间。 参与者在妊娠期间和分娩时提供了尿液和血液标本 胎儿超声检查，完成了一份有关接触来源的研究问卷，并同意医疗记录 使用权。我们将在存档的母尿中测量10个普遍的EPS，并将浓度与出生相关联 结局，新生儿肛门生殖器距离和阴茎尺寸，捕获超声和输送时。 我们将探讨共同暴露于EPS和PHT的影响，以及这些结果如何因种族而异。成功的 团队的经验确保了我们项目的完成，他们共同努力完成 先前的项目，并具有妇产科，生殖内分泌学，分析的必要专业知识 化学，流行病学和生物统计建模。这些数据将用于开发R01应用程序 支持一项更全面和机械的未来研究，以解决这一重要的生物医学研究 关于胎儿暴露于内分泌干扰化合物的种族不同发育影响的差距。