GASTRIC PLICATION FOR GERD AND GASTROPLASTY FOR OBESITY

治疗胃食管反流病的胃折叠术和治疗肥胖症的胃成形术

• 批准号: 7957967
• 负责人: KAREN S RICE
• 金额: $ 1.53万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957967
• 关键词: Acids; Adult; Affect; Animals; Attention; Client satisfaction; Computer Retrieval of Information on Scientific Projects Database; Esophageal; Excision; Functional disorder; Funding; Gastroesophageal reflux disease; Gastroplasty; Grant; Heartburn; High Prevalence; Individual; Institution; Obesity; Operative Surgical Procedures; Oral cavity; Outpatients; Overweight; Patients; Peptic Esophagitis; Pharmacotherapy; Physicians; Population; Prevalence; Primates; Procedures; Reflux; Research; Research Personnel; Resources; Safety; Societies; Source; Stomach; United States; United States National Institutes of Health; base; minimally invasive; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gastroesophageal reflux disease (GERD) affects millions of people worldwide. The prevalence of heartburn in a randomly selected adult population is approximately 20%. It is estimated that approximately one third of the adult population in the United States suffers from heartburn on a monthly basis and as many as 10% weekly. Of these, approximately 7% have reflux esophagitis. The management of GERD has gained increasing attention during the past two decades due to a high prevalence in Western societies, a better understanding of the pathophysiology, new potent anti-secretory drug therapies, the advent of minimally invasive surgery and new transoral, presentation through the mouth, endoscopic therapies. An outpatient endoscopic procedure that would alter the stomach esophageal barrier in the above described ways to prevent acid reflux would be appealing to patients and physicians alike. In this study, endoluminal gastroplication procedure will be studied. Obesity, defined as a BMI 30, is estimated to encompass about 1.7 billion individuals and the percentage of overweight adults is highest in the United States. We intend to achieve similar results with a procedure performed through the mouth that creates a restricted stomach pouch or gastroplasty, but with minimal invasiveness and maximal patient satisfaction. The planned animal trial will assist in determining the efficacy and safety of the procedure.For the obesity group end-points are to observe the safety and durability of the gastroplasty lines after mucosal patch excision.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 胃食管反流疾病（GERD）影响了全球数百万的人。随机选择的成人人群中胃灼热的患病率约为20％。据估计，美国大约三分之一的成年人口每月遭受胃灼热，每周多达10％。其中，大约7％的反流食管炎。在过去的二十年中，由于西方社会的高度流行，对病理生理学的高度流行，新的有效的抗分泌药物疗法，微创手术的出现和新的跨性能以及通过新的跨性能以及通过呈现方式，对GERD的管理一直受到了越来越多的关注。口，内窥镜疗法。 一种门诊内窥镜手术可以改变胃食管屏障的上述方法，以预防胃酸反流的方法将吸引患者和医生。在这项研究中，将研究内肢胃法。 肥胖症（定义为BMI 30）估计涵盖约17亿个人，并且超重成年人的百分比在美国最高。我们打算通过通过口腔执行的手术来实现相似的结果，从而产生受限的胃袋或胃成形术，但具有最小的侵入性和最大的患者满意度。计划中的动物试验将有助于确定该过程的功效和安全性。对于肥胖组，终点是观察粘膜切除后胃成形术线的安全性和耐用性。