BONE GRAFT SUBSTITUTE FOR INTER-BODY SPINAL FUSION

体间脊柱融合的骨移植替代品

• 批准号: 8172711
• 负责人: KAREN S RICE
• 金额: $ 9.06万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172711
• 关键词: Autologous; Bone Transplantation; Clinical; Computer Retrieval of Information on Scientific Projects Database; Funding; Gold; Grant; Healed; Hip Fractures; Implant; Institution; Laceration; Low Back Pain; Operative Surgical Procedures; Pain; Papio; Patients; Pelvis; Process; Research; Research Personnel; Resources; Societies; Source; Spinal Fusion; Testing; United States National Institutes of Health; Vertebral column; bone; healing; relating to nervous system; research study; vertebra body

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Spine ailments are amongst the most common and costly illnesses of today's societies. In the US alone, 30 billion dollars are spent annually for the surgical treatment of low back pain. About 400,000 such surgeries are performed every year. The gold standard, in 2008, still is to perform a spine fusion, using spongy bone of the patient's own pelvis (so called autologous iliac crest bone graft). To obtain the latter is often associated with prolonged pain (up to 30% of the patients), but also more serious complications such as vessel lacerations, neural damage, pelvic or hip fracture, etc. To use an artificial material that is forming a bone fusion just as bone does, would avoid taking bone from the pelvis. A new artificial material shall be tested in a baboon experiment for its clinical suitability. During a six month survival period the implant spacer is expected to bony integrate and thus form a stable bridge between the two adjacent vertebral bodies (this process is called a spine fusion). The artificial material is tested for achieving at least equal or possibly even better healing results compared to natural bone.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 脊柱疾病是当今社会最常见和最昂贵的疾病之一。仅在美国，每年就花费 300 亿美元用于腰痛的手术治疗。每年大约进行 40 万例此类手术。 2008年的金标准仍然是使用患者自己骨盆的松质骨（所谓的自体髂嵴骨移植）进行脊柱融合。获得后者通常会带来长期疼痛（高达 30% 的患者），而且还会出现更严重的并发症，如血管撕裂、神经损伤、骨盆或髋部骨折等。使用正在形成骨骼的人造材料就像骨头一样融合，可以避免从骨盆中取出骨头。新的人造材料应在狒狒实验中测试其临床适用性。 在六个月的生存期内，植入垫片预计会骨整合，从而在两个相邻椎体之间形成稳定的桥梁（此过程称为脊柱融合）。与天然骨相比，人造材料经过测试以实现至少相同或什至可能更好的愈合效果。