Superconducting Gradient Coil for Targeted Therapy by Micro-particle Navigation

用于微粒导航靶向治疗的超导梯度线圈

基本信息

批准号：
7612591
负责人：
Shahin Pourrahimi
金额：
$ 14.99万
依托单位：
SUPERCONDUCTING SYSTEMS, INC
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-26 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7612591
关键词：
Address Arteries Arts Benchmarking Blood Caliber Cancer Intervention Cancerous Characteristics Clinical Development Drug Delivery Systems Engineering Environment Equipment Heat Losses Heating Helium Human Image Invasive Laboratories Lead Life Liquid substance MRI Scans Magnetic Resonance Imaging Magnetism Medical Methods Modeling Movement Operative Surgical Procedures Performance Personal Satisfaction Pharmaceutical Preparations Phase Physiologic pulse Public Health Pulse taking Rate Running Safety Small Business Funding Mechanisms Small Business Innovation Research Grant Solutions Staging Stream Structure System Technology Temperature Testing Time Tissues United States Food and Drug Administration United States National Institutes of Health Work base clinically relevant cryogenics design in vivo innovation magnetic field nanorobotics new technology particle programs response size superconductivity

项目摘要

DESCRIPTION (provided by applicant): Our proposal introduces novel technologies that facilitate designing and manufacturing three-axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. The NanoRobotics Laboratory Ecole Polytechnique Montreal (NLEPM) has demonstrated principles of image-based particle navigation by use of MRI hardware. Recent work by NLEPM, who is a collaborator in our proposed work, has indicated a need for magnetic field gradients strength of hundreds of mT/m to navigate micro-particle that can be used as carries of drugs. Our proposed Phase I work intends to demonstrate the feasibility of design and manufacturing of superconducting gradient coils that can achieve 500 mT/m, and which can be installed inside clinical human MRI scanners. PUBLIC HEALTH RELEVANCE: Our proposal introduces novel technologies that facilitate designing and manufacturing three-axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue.

描述（由申请人提供）：我们的提案介绍了新型技术，这些技术促进了设计和制造三轴磁性梯度线圈，用于在人体动脉中的体内导航，可通过MRI扫描仪追踪。开发实用的体内粒子导航器可以导致非常有效的微创医疗治疗，也许最重要的是药物输送到癌组织。纳米机器人实验室Ecole Polytechnique Montreal（NLEPM）通过使用MRI硬件证明了基于图像的粒子导航原理。 NLEPM的最新工作是我们提出的工作中的合作者，他表明需要数百万种MT/m的磁场梯度强度来导航可用作药物携带的微颗粒。我们提出的I阶段工作旨在证明可以实现500 mt/m的超导梯度线圈的设计和制造的可行性，并且可以安装在临床人类MRI扫描仪中。公共卫生相关性：我们的提案介绍了新型技术，这些技术促进了设计和制造三轴磁性梯度线圈，用于在人类动脉中载有载体颗粒的体内导航，这些动脉可通过MRI扫描仪追踪。开发实用的体内粒子导航器可以导致非常有效的微创医疗治疗，也许最重要的是药物输送到癌组织。