Reducing the Size and Cost of MRI by Using a Zero-He Moderate-Field MRI Magnet Integrated with a Cryocooled RF Coil

通过使用与低温冷却射频线圈集成的零氦中场 MRI 磁体来减小 MRI 的尺寸和成本

• 批准号: 10081755
• 负责人: Shahin Pourrahimi
• 金额: $ 25.21万
• 依托单位: SUPERCONDUCTING SYSTEMS, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10081755
• 关键词: Adopted; Advanced Development; Ambulances; Applications Grants; Architecture; Beds; Devices; Economics; Funding; Goals; Head; Heart; International; Intervention; Limb structure; Magnetic Resonance Imaging; Manufacturer Name; Measurement; Measures; Medical Device; Noise; Operating Rooms; Performance; Phase; RF coil; Research; Resistance; Scanning; Ships; Signal Transduction; Small Business Innovation Research Grant; Sports; System; Technology; Temperature; Testing; Time; Work; cost; cryostat; design; innovation; point of care; programs; trend

Abstract: This application proposes to demonstrate that the more economic cryogen-free magnets operating at moderate fields of 0.5T-1T, and integrated with cryocooled RF coils, can produce signal to noise ratios (SNR) that are potentially comparable to those of 1.5 T MRI scanners with conventional RF coils. This project paves the way towards high-performance, smaller size, and lower cost MRI scanners suited to the emerging interventional and point-of-care applications. It is well established that reducing the RF coil resistance by cooling is advantageous for either small coils or low fields. Because the required scan time decreases in proportion to the square of SNR, even modest improvements in SNR are highly advantageous, especially in interventional and point-of-care situations. The first Aim of the Phase I effort is to demonstrate the feasibility of obtaining significantly higher SNR by conduction-cooling of RF receive coils, and establish the tradeoffs between field strength, magnet size (cost), and SNR gained by cryocooling of the RF receive coil. The second Aim of Phase I is to use results of this tradeoff study to design a practical cryogen-free magnet for head-MRI that includes an integrated cryocooled RF receive coil that will be built in Phase II of this work. The addition of cryocooled RF receive coils (higher SNR) to the magnet is provided at a small incremental cost to the magnet system. SSI, the applicant, has a proven record in the development of advanced cryogen-free MRI magnets under SBIR funding, and several international medical device companies have adopted (licensed) SSI’s MRI cryogen-free magnet technology.

抽象的： 该应用旨在证明更经济的无冷冻剂磁体 在 0.5T-1T 中等磁场下工作，并与低温冷却射频线圈集成，可以产生 信噪比 (SNR) 可能与 1.5 T MRI 扫描仪相当 该项目为高性能、更小尺寸和更小尺寸铺平了道路。 适合新兴介入和护理点应用的低成本 MRI 扫描仪。 众所周知，通过冷却降低射频线圈电阻对于以下任一方面都是有利的： 因为所需的扫描时间与平方成正比。 的信噪比，即使信噪比的适度改善也是非常有利的，特别是在 第一阶段工作的首要目标是证明介入和护理点情况。 通过射频接收线圈的传导冷却获得显着更高的信噪比的可行性， 并在场强、磁体尺寸（成本）和 SNR 之间进行权衡 第一阶段的第二个目标是利用这种权衡的结果。 研究设计一种用于头部 MRI 的实用无冷冻剂磁体，其中包括集成的 低温冷却射频接收线圈将在本工作的第二阶段建造。 为磁体提供射频接收线圈（更高的信噪比），但增加的成本却很小 申请人 SSI 在开发先进磁体系统方面拥有良好的记录。 SBIR 资助的无冷冻剂 MRI 磁体以及多种国际医疗设备 公司已采用（已获得许可）SSI 的 MRI 无冷冻剂磁体技术。