Reducing the Size and Cost of MRI by Using a Zero-He Moderate-Field MRI Magnet Integrated with a Cryocooled RF Coil

通过使用与低温冷却射频线圈集成的零氦中场 MRI 磁体来减小 MRI 的尺寸和成本

• 批准号: 10081755
• 负责人: Shahin Pourrahimi
• 金额: $ 25.21万
• 依托单位: SUPERCONDUCTING SYSTEMS, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10081755
• 关键词: Adopted; Advanced Development; Ambulances; Applications Grants; Architecture; Beds; Devices; Economics; Funding; Goals; Head; Heart; International; Intervention; Limb structure; Magnetic Resonance Imaging; Manufacturer Name; Measurement; Measures; Medical Device; Noise; Operating Rooms; Performance; Phase; RF coil; Research; Resistance; Scanning; Ships; Signal Transduction; Small Business Innovation Research Grant; Sports; System; Technology; Temperature; Testing; Time; Work; cost; cryostat; design; innovation; point of care; programs; trend

Abstract: This application proposes to demonstrate that the more economic cryogen-free magnets operating at moderate fields of 0.5T-1T, and integrated with cryocooled RF coils, can produce signal to noise ratios (SNR) that are potentially comparable to those of 1.5 T MRI scanners with conventional RF coils. This project paves the way towards high-performance, smaller size, and lower cost MRI scanners suited to the emerging interventional and point-of-care applications. It is well established that reducing the RF coil resistance by cooling is advantageous for either small coils or low fields. Because the required scan time decreases in proportion to the square of SNR, even modest improvements in SNR are highly advantageous, especially in interventional and point-of-care situations. The first Aim of the Phase I effort is to demonstrate the feasibility of obtaining significantly higher SNR by conduction-cooling of RF receive coils, and establish the tradeoffs between field strength, magnet size (cost), and SNR gained by cryocooling of the RF receive coil. The second Aim of Phase I is to use results of this tradeoff study to design a practical cryogen-free magnet for head-MRI that includes an integrated cryocooled RF receive coil that will be built in Phase II of this work. The addition of cryocooled RF receive coils (higher SNR) to the magnet is provided at a small incremental cost to the magnet system. SSI, the applicant, has a proven record in the development of advanced cryogen-free MRI magnets under SBIR funding, and several international medical device companies have adopted (licensed) SSI’s MRI cryogen-free magnet technology.

抽象的： 该申请提出的建议证明，无经济低温的磁铁 在0.5T-1T的中等场工作，并与冷冻RF线圈集成在一起，可以产生 信号与噪声比（SNR）可能与1.5 t MRI扫描仪可比 常规的RF线圈。该项目为高性能，尺寸较小的铺平了道路，并且 较低的成本MRI扫描仪适用于新兴介入和护理点应用。它 已经很好地确定，通过冷却来降低RF线圈电阻对于任何一种 小线圈或低场。因为所需的扫描时间与广场成比例下降 在SNR中，SNR的适度改进也非常有利，尤其是在 介入和护理的情况。我努力的第一个目的是证明 通过RF的传导冷却获得明显更高SNR的可行性接收线圈， 并建立野外强度，磁铁尺寸（成本）和SNR之间的权衡 RF的冷冻冷却接收线圈。第一阶段的第二个目的是使用此权衡的结果 研究设计用于头部MRI的实用无低温磁铁的研究，其中包括一个集成的 冻结的RF接收将在这项工作的第二阶段构建的线圈。添加了结coloded RF接收线圈（较高的SNR）向磁铁提供，以小额增量成本为 磁铁系统。适用的SSI在高级发展方面具有可靠的记录 SBIR资助下的无冷冻MRI磁铁和几种国际医疗设备 公司已采用（许可）SSI的无MRI低温磁铁技术。