Superconducting Gradient Coil for Targeted Therapy by Micro-particle Navigation

用于微粒导航靶向治疗的超导梯度线圈

基本信息

批准号：
8000932
负责人：
Shahin Pourrahimi
金额：
$ 56.5万
依托单位：
SUPERCONDUCTING SYSTEMS, INC
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-26 至 2012-11-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. The NanoRobotics Laboratory Ecole Polytechnique Montreal (NLEPM) has demonstrated principles of image-based particle navigation by use of MRI hardware. Recent work by NLEPM, who is a collaborator in our proposed work, has indicated a need for magnetic field gradient strength of hundreds of mT/m to navigate micro-particle that can be used as carries of drugs. Our proposed Phase II work intends to design and build fully functional superconducting gradient coils that can achieve 500 mT/m, which can be used in Navigation of micro-particles in midsize animals. PUBLIC HEALTH RELEVANCE: Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. In the Phase II program we will build and commission a fully functional superconducting gradient coil with gradient strength of 500 mT/m to demonstrate navigation of micro-particles in midsize animals.

描述（由申请人提供）：我们的提案介绍了新型技术，这些技术促进了设计和制造三轴磁性梯度线圈，用于在人类动脉中的体内导航，这些型号可以通过MRI扫描仪追踪。开发实用的体内粒子导航器可以导致非常有效的微创医疗治疗，也许最重要的是药物输送到癌组织。纳米机器人实验室Ecole Polytechnique Montreal（NLEPM）通过使用MRI硬件证明了基于图像的粒子导航原理。 NLEPM的最新工作是我们提出的工作中的合作者，他表明需要数百万种MT/m的磁场梯度强度来浏览可用作药物携带的微颗粒。我们提出的II期工作旨在设计和建立能够实现500 mt/m的功能齐全的超导梯度线圈，可用于中型动物的微粒导航。公共卫生相关性：我们的建议介绍了新型技术，这些技术促进了设计和制造三轴磁性梯度线圈，用于在人类动脉中携带颗粒的体内导航，这些动脉可通过MRI扫描仪追踪。开发实用的体内粒子导航器可以导致非常有效的微创医疗治疗，也许最重要的是药物输送到癌组织。在第二阶段计划中，我们将建立和委托具有500 mt/m梯度强度的功能齐全的超导梯度线圈，以证明中型动物中微粒的导航。