Hormonal responsive coding and non-coding genes in penile differentiation and hypospadias

阴茎分化和尿道下裂中的激素反应编码和非编码基因

• 批准号: nhmrc : 1138950
• 负责人: A/Pr Andrew Pask
• 金额: $ 56.47万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hormonal-responsive-coding-differentiation-hypospadias/1318906
• 关键词: Hormonal; responsive; coding; non; genes

Hypospadias, a failure of the correct formation of the penis, is the second-most common birth defect, occurring in around 1% of boys. It causes distress to both newborn and parents, requiring surgical intervention, and is a burden of cost and is a risk to the child. Furthermore, it is frequently associated with other abnormalities. We have a novel model in which we can induce penis abnormalities and define the link between hormonal exposures and defective penis differentiation.

尿道下裂是阴茎无法正确形成的一种疾病，是第二常见的出生缺陷，大约有 1% 的男孩发生这种情况。它会给新生儿和父母带来痛苦，需要进行手术干预，并且是费用负担，并且对孩子来说是一种风险。此外，它经常与其他异常相关。我们有一个新的模型，可以在其中诱导阴茎异常，并确定激素暴露与有缺陷的阴茎分化之间的联系。