Ovarian differentiation and sex reversal

卵巢分化和性逆转

• 批准号: nhmrc : 454367
• 负责人: A/Pr Andrew Pask
• 金额: $ 33.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ovarian-differentiation-sex-reversal/97185
• 关键词: Ovarian; differentiation; sex; reversal

Defects of the internal and external genitalia are among the most common birth defects in babies (1 in 4,000 births) yet the aetiology in many cases is unclear. We will compare and contrast the mouse with a unique animal model the tammar wallaby to investigate the control of ovarian differentiation during early fetal and postnatal life. The gonad is unusual in that two completely different organs arise from the same precursor tissues, so that errors in development lead to intersexual phenotypes. Some intersexual conditions are the result of inappropriate exposure to hormones during fetal life, and others are due to spontaneous or inherited gene mutations. About 5-10% of ovarian cancer cases, that affect 1 in 8000 Australian women, are due to the inheritance of a faulty gene. We will use comparative analysis and an inducible sex reversal system to understand the way gene expression and hence tissue differentiation is altered between male and female during the formation of the ovary versus the testis. This will inform us about the causes and consequences of normal and abnormal sexual development, infertility and gonadal malignancies.

内部和外生殖器的缺陷是婴儿最常见的先天缺陷之一（四分之一的分娩），但在许多情况下，病因尚不清楚。我们将将小鼠与独特的动物模型进行比较和对比，以研究早期胎儿和产后生活期间卵巢分化的控制。性腺是不寻常的，因为两个完全不同的器官来自相同的前体组织，因此发育中的错误导致了性交表型。某些两性条件是胎儿生活中不适当暴露于激素的结果，而另一些是由于自发或遗传基因突变引起的。大约5-10％的卵巢癌病例影响了8000名澳大利亚妇女中有1例是由于遗传错误的基因。我们将使用比较分析和诱导性逆转系统来了解基因表达以及在卵巢形成期间男性和女性之间的组织分化的方式。这将为我们提供正常和异常性发展，不育和性腺恶性肿瘤的原因和后果。