Hypospadias and control of urethral closure

尿道下裂和尿道闭合的控制

• 批准号: nhmrc : 1063356
• 负责人: A/Pr Andrew Pask
• 金额: $ 48.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hypospadias-control-urethral-closure/455051
• 关键词: Hypospadias; control; urethral; closure

Hypospadias, is a common defect, in which the urethra opens abnormally along the shaft of the penis not at the tip. It affects 1 in every 125 boys born in Victoria each year. However, the cause(s) of over two-thirds of these cases cannot be explained. Our studies using marsupials show that this process is mediated by a hormone (5alpha-androstanediol), with previously undetermined physiological function. This study will provide novel data on the interactions of the genes and hormones that result in defects of penile development.

尿道下裂是一种常见的缺陷，尿道沿着阴茎干而不是尖端异常打开。每年在维多利亚州出生的男孩中，每 125 名就有 1 名受到影响。然而，超过三分之二的案件的原因无法解释。我们对有袋动物的研究表明，这一过程是由一种激素（5α-雄甾烷二醇）介导的，其生理功能此前尚未确定。这项研究将提供有关导致阴茎发育缺陷的基因和激素相互作用的新数据。