Testis to ovary: hormonal control of differentiation

睾丸到卵巢：分化的激素控制

• 批准号: nhmrc : 1010453
• 负责人: A/Pr Andrew Pask
• 金额: $ 53.57万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/testis-ovary-hormonal-control-differentiation/109495
• 关键词: Testis; ovary; hormonal; control; differentiation

We know very little of the genes that control development of the ovary in female fetuses; most study has focused on the formation of the testis in males. We will use a novel experimental model, a marsupial, where by hormonal treatment of developing males we can switch off testis formation and activate the ovarian pathway. These studies will potentially shed new light on the causes of reproductive diseases including ovarian cancer, as well as clarifying the basic biological processes that guide formation of the ovary.

我们对控制女性胎儿卵巢发育的基因知之甚少。大多数研究都集中在男性睾丸的形成上。我们将使用一种新颖的实验模型，即有袋动物，通过对发育中的雄性进行激素治疗，我们可以关闭睾丸形成并激活卵巢途径。这些研究将有可能为包括卵巢癌在内的生殖疾病的病因提供新的线索，并阐明指导卵巢形成的基本生物过程。