Xenobiotic-responsive hepatic long non-coding RNAs

异生素反应性肝脏长非编码RNA

基本信息

批准号：
10711162
负责人：
DAVID J WAXMAN
金额：
$ 3.49万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-12-16 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10711162
关键词：
Address Adult Affect Agonist Architecture Automobile Driving Award Bioinformatics Biological Process CRISPR interference Cell Communication Cells Chemicals Code Data Analyses Development Diet Dietary Fats Disease Disease Progression Educational Status Epigenetic Process Etiology Evaluation Exposure to Gene Expression Profile Genes Genetic Transcription Health Hepatic Hepatocyte High Fat Diet Knockout Mice Ligands Link Liver Liver Cirrhosis Liver Fibrosis Liver diseases Mediator Mentors Metabolic Pathway Mitochondria Modeling Molecular Mus Nuclear Receptors Parents Pathologic Pathology Pathway interactions Physiological Positioning Attribute Primary carcinoma of the liver cells Process Proteins Qualifying RNA Regimen Research Research Training Role Scheme Small Nuclear RNA Specificity Techniques Time Training Underrepresented Minority Untranslated RNA Xenobiotics cell type disorder risk doctoral student environmental chemical environmental toxicology epigenome editing experience fatty liver disease gene network immune cell infiltrate in vivo insight interest laboratory experiment lipid metabolism liver metabolism mouse model non-alcoholic fatty liver disease nonalcoholic steatohepatitis novel marker parent grant programs promoter prototype receptor therapeutic target transcription factor transcription termination transcriptome sequencing transcriptomic profiling underrepresented minority student

项目摘要

Diversity Supplement Application – ES024421, Waxman DJ, PI Project Summary/Abstract - This application is for a Research Supplement to Promote Diversity in Health-Related Research (PA-21-071) in support of a qualified underrepresented minority PhD student who will receive graduate level training in molecular environmental toxicology under parent grant, ES024421. The proposed training and mentoring program will use the mouse model to advance our understanding of the interactions of nuclear receptors when activated by foreign, environmental chemicals, with exposure to high fat dietary regimens, with a focus on interactions that impact the development and progression of fatty liver disease. These studies are closely related to, and will significantly advance progress under the parent grant, and will provide the qualified underrepresented minority PhD student with training and experience in a broad range of wet lab experimental, data analysis and bioinformatics techniques to address cutting edge research problems in molecular environmental toxicology.

多样性补充申请 – ES024421，Waxman DJ，PI 项目摘要/摘要 - 此应用程序是为了促进研究补充健康相关研究的多样性 (PA-21-071)，支持合格的代表性不足的人少数族裔博士生将接受分子环境方面的研究生水平培训毒理学根据家长资助，ES024421 拟议的培训和指导计划将。使用小鼠模型加深我们对核受体相互作用的理解当被外来环境化学物质激活，并暴露于高脂肪饮食时治疗方案，重点关注影响脂肪肝发展和进展的相互作用这些研究与肝脏疾病密切相关，并将显着推动进展。根据家长补助金，并将提供合格的代表性不足的少数族裔博士生在广泛的湿实验室实验、数据分析和生物信息学技术解决分子领域的前沿研究问题环境毒理学。