EFFECT OF N-3 FATTY ACIDS ON LIVER FAT CONTENT

N-3 脂肪酸对肝脏脂肪含量的影响

• 批准号: 7377622
• 负责人: Scott M. Grundy
• 金额: $ 0.68万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377622
• 关键词: EFFECT; FATTY; ACIDS; LIVER; FAT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study has two specific aims: 1) to determine whether there is an association between insulin resistance and liver fat content and 2) to determine whether n-3 polyunsaturated fatty acids reduce the amount of fat in the liver. Obesity is frequently accompanied by non-alcoholic fatty liver (NAFL). However, not all obese subjects have increased hepatic fat. In the first aim, it will be determined if obese subjects with NAFL have insulin resistance of muscle and adipose tissue. Insulin resistance of muscle will be studied by quantitation of insulin-mediated uptake of glucose, insulin resistance of adipose tissue will be investigated through parameters of metabolism of nonesterified free fatty acids (NEDA). N-3 polyunsaturated fatty acids [eicosopentanoic acid (EPA) and docosahexaenoic acid (DHA)] have multiple effects on fatty acid and triglyceride metabolism and administration of these fatty acids to humans results in a reduction of plasma triglyceride levels. In this projects we will determine the therapeutic efficacy of fish oils (a mixture of EPA and DHA) at reducing hepatic fat content in NAFL. Measurements also will be made of fat content of skeletal muscle and heart.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。这项研究有两个具体目的：1) 确定胰岛素抵抗和肝脏脂肪含量之间是否存在关联；2) 确定 n-3 多不饱和脂肪酸是否可以减少肝脏中的脂肪量。肥胖常常伴有非酒精性脂肪肝（NAFL）。然而，并非所有肥胖受试者的肝脂肪都会增加。第一个目标是确定患有 NAFL 的肥胖受试者是否具有肌肉和脂肪组织的胰岛素抵抗。通过定量胰岛素介导的葡萄糖摄取来研究肌肉的胰岛素抵抗，通过非酯化游离脂肪酸（NEDA）的代谢参数来研究脂肪组织的胰岛素抵抗。 N-3 多不饱和脂肪酸 [二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA)] 对脂肪酸和甘油三酯代谢具有多种影响，人体服用这些脂肪酸会导致血浆甘油三酯水平降低。在这个项目中，我们将确定鱼油（EPA 和 DHA 的混合物）在降低 NAFL 中肝脂肪含量方面的治疗效果。还将测量骨骼肌和心脏的脂肪含量。