COMPARISON OF TRIGLYCERIDES ON PLASMA LEVELS OF BETAHYDROXYBUTERANE

甘油三酯对β-羟基丁烷血浆水平的比较

• 批准号: 7377653
• 负责人: Scott M. Grundy
• 金额: $ 1.62万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377653
• 关键词: COMPARISON; TRIGLYCERIDES; PLASMA; LEVELS; BETAHYDROXYBUTERANE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this pilot study is to determine whether Medium Chain Triglycerides (MCT) are better than Long Chain Triglycerides (LCT) in measuring fatty acid oxidation. Fatty acids are a source of energy and generally these fats are converted to acetyl coenzyme A in the mitochondria in the process of beta-oxidation. This assessment was done by other investigators using a fat tolerance test carried out over a 10 to 12 hour interval. Levels of beta-hydroxybutyrate (BHB) were measured and the area under the curve was calculated. The method was useful in detecting significant differences of about 15 to 20% between healthy subjects and those with familial combined hyperlipidemia. Also, somewhat greater differences were found between women and men. The study objective is to compare BHB curves during intake of two oral fat loads that consist of either long-chain triglycerides (LCT) or medium-chain triglycerides (MCT). LCT consists of fatty acids that have 12 to 20 carbon atoms; MCT contain fatty acids that are 8 to 12 carbon atoms in length. The difference in chain length and other properties of MCT, as detailed below, will allow MCT to undergo beta-oxidation to a greater extent than LCT. The net effect should be that plasma levels of BHB will be higher during the ingestion of MCT than LCT.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项试验研究的目的是确定中链甘油三酸酯（MCT）是否比长链甘油三酸酯（LCT）更好地测量脂肪酸氧化。脂肪酸是能量的来源，通常在β-氧化过程中，这些脂肪在线粒体中转化为乙酰辅酶A。该评估是由其他研究人员使用脂肪耐受性测试进行10到12小时的时间进行的。测量了β-羟基丁酸酯（BHB）的水平，并计算曲线下的面积。该方法可用于检测健康受试者和家族性综合高脂血症患者之间约15％至20％的显着差异。同样，男女之间发现了更大的差异。 该研究的目标是比较在摄入两个口腔脂肪载荷期间，由长链甘油三酸酯（LCT）或中链甘油三酸酯（MCT）组成。 LCT由具有12至20个碳原子的脂肪酸组成； MCT含有长度为8至12个碳原子的脂肪酸。如下所述，MCT的链长度和其他特性的差异将使MCT比LCT更大程度地进行β-氧化。净效应应是，在摄入MCT期间，BHB的血浆水平将高于LCT。