GENETIC POLYMORPHISMS OF HEPATIC LIPASE

肝脂肪酶的基因多态性

• 批准号: 6567644
• 负责人: Scott M. Grundy
• 金额: $ 32.14万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6567644
• 关键词: atherosclerosis; blood lipoprotein metabolism; clinical research; coronary disorder; disease /disorder proneness /risk; enzyme mechanism; gene expression; genetic polymorphism; genetic regulation; hepatic lipase; high density lipoproteins; human subject

The purpose of this project will be to evaluate the influence of recently identified polymorphisms of the hepatic lipase gene on plasma HDL levels, on lipoprotein metabolism, and on risk for CHD. In addition we will seek for new polymorphisms in the hepatic lipase gene for which in vivo and in vitro expression studies can be carried out. The proposed studies should contribute to our understanding of the genetic regulation of hepatic lipase and the functional significance of this enzyme.

该项目的目的是评估 最近发现血浆中肝脂肪酶基因的多态性 高密度脂蛋白水平、脂蛋白代谢和冠心病风险。 此外 我们将寻找肝脂肪酶基因的新多态性 可以进行体内和体外表达研究。 这 拟议的研究应有助于我们对遗传的理解 肝脂肪酶的调节及其功能意义 酶。