CAUSES AND MANAGEMENT OF PRIMARY HYPERCHOLESTEROLEMIA

原发性高胆固醇血症的原因和治疗

• 批准号: 6567641
• 负责人: Scott M. Grundy
• 金额: $ 32.14万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6567641
• 关键词: antihyperlipoproteinemic agent; blood disorder chemotherapy; blood lipoprotein metabolism; clinical research; combination therapy; diet therapy; dietary lipid; drug adverse effect; drug screening /evaluation; human subject; human therapy evaluation; hypercholesterolemia; low density lipoprotein; metabolism disorder chemotherapy; nutrition related tag; very low density lipoprotein

This NIH project examines lipoprotein defects, evaluates clinical significance and the need to treat. Treatment options under investigation include role of individual dietary fatty acids and the mode of action, safety and efficacy of single and combined drug therapy. Metabolic unit studies are conducted as well as kinetic studies. Metabolism and underlying defects in lipoproteins are being minutely analysed. Source of research material is plasma lipoproteins throughout the different study phases. LDL/VLDL turnover studies will be utilized.

该 NIH 项目检查脂蛋白缺陷，评估临床 治疗的意义和必要性。 治疗方案如下 调查包括个体膳食脂肪酸的作用和 单一和联合药物治疗的作用方式、安全性和有效性。 进行代谢单位研究以及动力学研究。 脂蛋白的代谢和潜在缺陷正在被详细研究 分析了。研究材料的来源是血浆脂蛋白 不同的学习阶段。将利用 LDL/VLDL 周转研究。