Clinical Trials Network: North Texas Node

临床试验网络：北德克萨斯节点

• 批准号: 7437555
• 负责人: BRYON H. ADINOFF
• 金额: $ 22.96万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7437555
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Admission activity; Adolescent; Adult; African American; Alcohol abuse; Alcohol or Other Drugs use; Algorithms; Ancillary Study; Attention Deficit Disorder; Award; Bipolar Disorder; Characteristics; Child; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials Network; Cognitive Therapy; Collaborations; Commit; Communities; Complement; Complex; Condition; Depressed mood; Development; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Drug abuse; Drug usage; Effectiveness; Exhibits; Faculty; Fellowship; Female; Female Adolescents; Foundations; Funding; Future; Geographic Locations; Grant; HIV; Health; Health Personnel; Hispanics; Hospitals; Inpatients; Investigation; Joints; K-Series Research Career Programs; Latino; Lead; Medical center; Mental Depression; Mental disorders; Monitor; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Outpatients; Patients; Pattern; Performance; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Policies; Population; Prevention; Primary Health Care; Procedures; Protocols documentation; Provider; Psychiatrist; Public Health; Range; Recording of previous events; Research; Research Personnel; Research Proposals; Research Training; Residencies; Risk; Screening procedure; Services; Site; Structure; Substance Use Disorder; Substance abuse problem; System; Texas; Training; Training and Education; United States National Institutes of Health; Universities; Vision; Voice; Woman; Work; addiction; austin; career; clinical research site; concept; court; data management; design; effectiveness clinical trial; experience; health care service utilization; interest; medical specialties; organizational structure; outreach program; pre-clinical; pre-doctoral; programs; response; success; transmission process

This application proposes a new ClinicalTrials Network(CTN) node representing North Texas. The North Texas Node (NTN) is comprised of the University of Texas Southwestern Medical Center in Dallas (TIT Southwestern) and seven Community Treatment Providers (CTPs) in Dallas, Ft. Worth, Austin,and El Paso. UT Southwesternbrings together a faculty with extensive experience in the preclinical and clinical study of substance u&edisorders, the design, implementation, and analysis of multi-site, efficacy-effectiveness clinical trials in both adolescents and adults the pharmacological treatment of comorbid disorders, and cultural issues in addiction. UT Southwestern faculty will collaborate with CTPs representing over 11,000 annual inpatient and outpatient admissions for a primary substance use disorder, with large populations of Hispanic/Latino, African-American, adolescent, and female patients. The CTPs and associated sites also offer specialized treatment and outreach programs for HIV+ patients. The NTN utilizes an administrative and organizational structure that carefully considers the CTN structure, its policies and procedures, and the initiation of centralized clinical,data management/statistical, and logistical centers. The Node's organization also provides a strong voice to our CTPs, assuring their presence on all committees,teams, and workgroups. For example, the NTN has initiated mechanisms to develop new protocols that involve a joint CTP- UT Southwestern effort, as evidenced by our Concept Proposal that addresses an unmet clinicalneed identified by the Node's CTPs. This collaborative structure will enable the NTN to take the lead in the development of future of protocols within the CTN, in addition to ancillary and externally funded studies that maximize the CTN platform. This system also incorporates UT Southwestern's preclinical T32 and clinical R25 NIDA training grants to encourage resident, fellow, and faculty career development within the CTN, includingK awards. Protocol implementation will be assured by our exceptionally skilled management team and trainers from UT Southwestern's previous and ongoing multi-site clinical trials and a cadre of CTP sites with significant collaborative research experience.The effectiveness of the NTN in developing, implementing and disseminatingthe results of clinicaltrials will be assisted by the NTN's own Performance Assessment System, which will complement the CTN's performance monitors. Our ConceptProposal, which proposes a study of the effects of medication algorithms to treat adolescents with substance use and comorbid disorders, reveals our Node's ability to design state-of-the-arteffectiveness trials that maximize the potential of the CTN framework. We believe the structure and organization of the NTN, as well as its committed and highly experienced investigators, complements and extends the work of the CTN.

该应用程序提出了一个代表北德克萨斯州的新临床试验网络（CTN）节点。北德克萨斯州 Node (NTN) 由位于达拉斯的德克萨斯大学西南医学中心 (TIT Southwestern) 和 位于达拉斯的七家社区治疗提供者 (CTP)。沃斯、奥斯汀和埃尔帕索。 UT西南带来 汇集了在物质和疾病的临床前和临床研究、设计、 在青少年和成人中进行多中心疗效-效果临床试验的实施和分析 共病的药物治疗以及成瘾的文化问题。 UT西南大学的教职人员将 与代表每年超过 11,000 例主要药物使用住院和门诊入院的 CTP 合作 疾病，有大量西班牙裔/拉丁裔、非裔美国人、青少年和女性患者。 CTP 和 相关站点还为 HIV + 患者提供专门的治疗和外展计划。 NTN 采用的行政和组织结构仔细考虑了 CTN 的结构、其 政策和程序，以及集中临床、数据管理/统计和后勤中心的启动。 节点组织还为我们的 CTP 提供了强有力的声音，确保他们在所有委员会、团队、 和工作组。例如，NTN 启动了开发新协议的机制，其中涉及联合 CTP- UT Southwestern 的努力，正如我们的概念提案所证明的那样，该提案解决了由 节点的 CTP。这种协作结构将使 NTN 能够在未来的发展中处于领先地位。 CTN 内的协议，以及最大化 CTN 平台的辅助和外部资助的研究。这 系统还纳入了 UT Southwestern 的临床前 T32 和临床 R25 NIDA 培训补助金，以鼓励 CTN 内的住院医师、研究员和教员职业发展，包括 K 奖。协议实施将 我们技术精湛的管理团队和来自 UT 西南大学以前和现在的培训师保证了这一点 多中心临床试验和具有丰富合作研究经验的 CTP 中心骨干队伍。 NTN 自己的部门将协助 NTN 制定、实施和传播临床试验结果 绩效评估系统，它将补充 CTN 的绩效监控器。我们的概念提案， 提出了一项药物算法对治疗青少年药物滥用和共病的影响的研究 疾病，揭示了我们的节点设计最先进的有效性试验的能力，以最大限度地发挥疾病的潜力 CTN框架。我们相信NTN的结构和组织，以及它的承诺和高度 经验丰富的调查员补充并扩展了 CTN 的工作。