Neurocognitive Change Associated w/ Behavioral Treatment

与行为治疗相关的神经认知变化

• 批准号: 7413898
• 负责人: KENT A KIEHL
• 金额: $ 45.84万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7413898
• 关键词: amygdala; antisocial personality; behavior prediction; behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; cocaine; cognitive behavior therapy; counseling; craving; evoked potentials; functional magnetic resonance imaging; hemodynamics; hippocampus; human subject; human therapy evaluation; longitudinal human study; motivation; neuroimaging; neurophysiology; neuropsychology; parietal lobe /cortex; patient oriented research; prefrontal lobe /cortex; relapse /recurrence; visual stimulus

DESCRIPTION (provided by applicant): Heavy cocaine users who repeatedly fail in treatment account for a disproportionately large share of cocaine consumption and associated demand of community health resources. We have recently developed a tailored cognitive behavioral treatment protocol for the treatment of cocaine abuse. In a large study (n=157), our tailored treatment protocol, Substance Expectation Therapy (SET), was compared to Relapse Prevention (RP) and Addiction Counseling (AC) for the treatment of cocaine abuse (NIDA R01; PI Jaffe). SET was found to be superior to RP and AC for preventing relapse in cocaine abusers. A major aim of this proposal is to replicate the efficacy of SET for the treatment of cocaine abusers. A second major aim of this proposal is to build upon research that has shown abnormalities in the brain's response to distracting stimuli predicts relapse in cocaine abusers. We will use multimodal brain imaging, combined with advanced image processing techniques, including Independent Components Analyses, to further delineate the neurocognitive systems that convey risk for relapse in cocaine abusers. In addition, this proposal will examine changes in neurocognitive systems associated response inhibition, deviance detection, salient stimulus processing and expectancy across the three treatment protocols (SET, RP, and AC). Our primary hypotheses are that SET will be superior to RP and AC for preventing relapse in cocaine abuses. It is also hypothesized that multimodal, compared to unimodal, brain imaging will convey superior predictive power for assessing relapse in cocaine abusers. Finally, we hypothesize that SET therapy will show increased modulation in the brain systems associated with inhibitory processing and expectancy over the course of the 12 week treatment protocol. In summary, the results of this proposal will test the efficacy of SET therapy compared to RP and AC, will further delineate the functional architecture underlying risk for relapse in cocaine abusers, and will examine neuronal changes associated with tailored cognitive-behavioral therapy.

描述（由申请人提供）：重大可卡因用户反复失败的可卡因消费份额和相关社区卫生资源需求的比例不成比例。我们最近开发了一种量身定制的认知行为治疗方案，用于治疗可卡因滥用。在一项大型研究（n = 157）中，我们的量身定制治疗方案，物质预期治疗（SET）与预防复发（RP）和成瘾咨询（AC）进行了比较，以治疗可卡因滥用（NIDA R01; PI JAFFE）。发现集合优于RP和AC，可防止可卡因滥用者复发。该提案的主要目的是复制设置可卡因滥用者的功效。该提案的第二个主要目的是基于研究表明大脑对分散注意力刺激的反应异常的研究预测可卡因滥用者的复发。我们将使用多模式的脑成像，再加上包括独立组件分析在内的先进图像处理技术，进一步描述神经认知系统，这些神经认知系统传达了可卡因施虐者中复发风险的风险。此外，该建议将检查神经认知系统的变化相关的响应抑制，偏差检测，显着刺激处理以及在三种治疗方案（SET，RP和AC）中的期望。我们的主要假设是集合将优于RP和AC，以防止可卡因滥用。还可以假设，与单峰相比，多模式将传达出卓越的预测能力，以评估可卡因滥用者的复发。最后，我们假设在12周治疗方案过程中，SET治疗将显示与抑制性处理和期望相关的大脑系统中的调节增加。总而言之，该提案的结果将测试与RP和AC相比，将测试设定治疗的功效，将进一步描述可卡因滥用者复发风险的功能性结构，并将检查与量身定制的认知行为 - 行为 - 行为治疗相关的神经元变化。