COBRE: RIH: CORE B: PROTEOMICS: PROTEIN BIOINFORMATICS, HU GENOME, DNA

COBRE：RIH：核心 B：蛋白质组学：蛋白质生物信息学、HU 基因组、DNA

• 批准号: 7171097
• 负责人: DJURO JOSIC
• 金额: $ 57.67万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171097
• 关键词: clinical research; health science research potential; neoplasm /cancer

DESCRIPTION (provided by applicant): The mission of the Center for Cancer Research Development is to coalesce and foster outstanding, interactive, laboratory-based cancer research centered on the Molecular and Cellular Pathogenesis of Cancer. To this end, three program projects, each with two subprojects will be initiated in year one along with four pilot projects, the latter supported by funds from Rhode Island Hospital/Academic Medical Center (RIH/AMC). The goal will be to develop program projects in four different but related themes, into interactive research groups composed of at least 3 junior investigators supported by peer reviewed grants. This will be accomplished by establishing and perpetuating an intellectually dynamic training environment in which junior investigators will create and disseminate new knowledge and clinical applications and with the guidance of senior faculty mentors, build nationally competitive, independent, but interactive research programs. The investigators will utilize common model systems and state-of-the-art core facilities in administration, career development, proteomics and molecular pathology to 1) discover mechanisms leading to neoplasia and 2) develop clinical applications resulting from this knowledge. The six subprojects, mentored by a team of seven senior faculty including the PI and Co-PI, target programmatic themes in gastrointestinal cancer, developmental proteins and intracellular signaling pathways. A fourth theme in viral mechanisms of carcinogenesis is represented by pilot projects funded by the institution. The proposal represents a strategic partnership in which RIH/AMC will commit significant resources to supplement those requested in this application to build cohesive strength in basic cancer research that complements existing strengths in clinical cancer treatment, outreach, and prevention. The long-term goal of this support is to achieve NCI designation as a Comprehensive Cancer Center. Guidance for the Center will be provided by teams of Internal and External Advisors and Consultants including a Translational Research Group together with a carefully considered plan of training, evaluation and succession. The end result will be a Cancer Research Center of investigators with significant programmatic strengths and translational impact.

描述（由申请人提供）：癌症研究开发中心的使命是结合并促进以癌症分子和细胞发病机理为中心的杰出，互动，基于实验室的癌症研究。为此，三个计划项目，每个项目都将在第一年与四个试点项目一起启动，后者得到了罗德岛医院/学术医疗中心（RIH/AMC）的资金的支持。目的是将以四个不同但相关的主题开发为互动研究小组，由至少3名由同行评审的赠款支持的初级调查人员组成。 这将通过建立和永久延续一个智力动态培训环境来实现，在该环境中，初级调查人员将创建和传播新的知识和临床应用，并在高级教师导师的指导下建立全国竞争，独立但互动研究计划。研究人员将利用通用模型系统和最先进的核心设施，用于管理，职业发展，蛋白质组学和分子病理学1）发现导致肿瘤的机制； 2）根据这些知识产生的临床应用。由七个高级教师组成的团队（包括PI和CO-PI）的六个副标题，胃肠癌，发育蛋白和细胞内信号通路的目标程序主题。癌变病毒机制的第四个主题由该机构资助的试点项目代表。该提案代表了一种战略伙伴关系，其中RIH/AMC将投入大量资源，以补充本应用程序中要求的人，以在基本癌症研究中建立凝聚力的力量，以补充临床癌症治疗，外展和预防中现有的优势。这种支持的长期目标是将NCI指定为全面的癌症中心。内部和外部顾问和顾问团队将提供该中心的指南，包括翻译研究小组，以及经过精心考虑的培训，评估和继承计划。最终结果将是一个具有重大程序性优势和翻译影响的研究中心的癌症研究中心。