Developmental Research Program

发展研究计划

• 批准号: 10554479
• 负责人: Eric R. Fearon
• 金额: $ 15.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-14 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554479
• 关键词: Advertisements; Award; Basic Science; Biometry; Budgets; Cancer Center; Clinical; Collaborations; Communities; Data Reporting; Development; Early treatment; Elements; Ensure; Evaluation; Exclusion; Faculty; Feedback; Fostering; Funding; Future; Goals; Grant; Human; Institution; Laboratories; Locally Advanced Malignant Neoplasm; Mentors; Mentorship; Michigan; Molecular Target; Monitor; Outcome; Population Research; Process; Program Research Project Grants; Protocols documentation; Radiation therapy; Radiosensitization; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Schedule; Seasons; Treatment-Related Cancer; United States National Institutes of Health; Universities; Writing; anticancer research; career; data submission; expectation; high risk; innovation; member; novel; operation; peer; pre-clinical; programs; translational impact; translational potential; web site

PROJECT SUMMARY-ABSTRACT (DEVELOPMENTAL RESEARCH PROGRAM) Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As such, we will support 3 developmental research projects with budgets of approximately $50,000 each per year. The principal goal of the Developmental Research Program (DRP) is to support highly innovative radiation therapy related cancer research with high potential for translational impact, allowing investigators the ability to obtain key preliminary data for submission of an R01 application or an equivalent proposal (e.g. project in future SPORE application). A maximum of two years of support will be possible; however, the expectation is that funds will support most projects for one year, with 10-15 new projects supported during the five-year period of the grant. Projects will be solicited from University of Michigan Rogel Cancer Center investigators and other University of Michigan faculty by campus-wide announcements and a standing advertisement for the Program at the Cancer Center and institutional websites listing other developmental research opportunities. Applications will utilize an NIH format, with a 5-page limit on the body of the application (e.g. excluding references, detailed protocol information, appendix materials). Drs. Eric Fearon and Theodore Lawrence will serve as Co-Directors of the DRP. The Cancer Research Committee of the University of Michigan Rogel Cancer Center will undertake initial review, evaluating each proposal’s scientific merit, innovation, relevance to the theme of radiosensitization of locally advanced cancers and potential for translational impact. Given the Cancer Research Committee’s rapid and successful annual review of more than 100 pilot research proposals yearly in laboratory, clinical, and population-based research, the Committee is well-suited for the initial review process. After initial review, the SPORE’s Operations Committee will utilize assigned merit scores as a principal, but not sole, criterion in the selection of proposals for support. Developmental research project investigators will take part in all SPORE activities. Drs. Fearon or Lawrence will join mentoring committees set up for each project PI to offer in-depth review and mentorship.

项目摘要提取（发展研究计划） 对发展研究项目的支持是关键的孢子元素，对 促进开拓性计划。因此，我们将支持三个开发研究项目 每年的预算约为50,000美元。发展的主要目标 研究计划（DRP）是为了支持高度创新的放射治疗相关癌症 具有高潜力转化影响的研究，使研究人员能够 获取关键的初步数据以提交R01应用程序或等效 提案（例如未来孢子应用中的项目）。最多两年的支持将是 可能的;但是，期望资金将为大多数项目提供一年的支持， 赠款五年期间支持的10-15个新项目。项目将被巩固 来自密歇根大学Rogel Cancer Center研究人员和其他密歇根大学 校园范围内的公告和该计划的常设广告 癌症中心和机构网站列出了其他发展研究机会。 应用程序将使用NIH格式，对应用程序的正文有5页的限制（例如， 不包括参考文献，详细协议信息，附录材料）。博士。埃里克·费顿（Eric Fearon）和 西奥多·劳伦斯（Theodore Lawrence）将担任DRP的联合导演。癌症研究 密歇根大学罗杰尔癌症中心委员会将进行初步审查， 评估每个提案的科学优点，创新，与主题相关 局部高级癌症的放射敏化和翻译影响的潜力。给出 癌症研究委员会对100多个飞行员的快速而成功的年度审查 每年在实验室，临床和人群研究中提出的研究建议， 委员会非常适合初步审查过程。在初次审查后，孢子的 运营委员会将利用指定的优异成绩作为委托人，但不是唯一的标准 选择支持建议。发展研究项目调查人员将参加 所有孢子活动。博士。 Fearon或Lawrence将加入为每个设立的指导委员会 PI Project PI提供深入的审查和指导。