Pilot Projects-Tran-Network

试点项目-跨网

• 批准号: 10733238
• 负责人: Nicolas Skuli
• 金额: $ 3.29万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-05 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733238
• 关键词: Address; Basic Science; Budgets; Cancer Center; Clinic; Clinical; Collaborations; Common Neoplasm; Communities; Complement; Data; Development; Disabled Persons; Ensure; Equity; Evaluation; Faculty; Financial Support; Fostering; Funding; Goals; Grant; Human Resources; Intervention; Methodology; Monitor; Pennsylvania; Pilot Projects; Process; Progress Reports; Racial Equity; Research; Research Personnel; Resources; Technology; Testing; Tissue Banks; Tissue Expansion; Translational Research; Underrepresented Minority; Universities; Work; cancer health disparity; health care disparity; high risk; innovation; novel; novel strategies; patient derived xenograft model; programs; recruit; research and development; success; tissue resource; tool; translational potential; women with disabilities

Summary: The goals of the Pilot Projects and Trans-Network Activities Core of the UP-PDTC focus on two priorities. First, the Core will promote and support new Pilot Projects with high scientific merit and innovation that will strongly impact PDX model development research and/or have the potential for translation to the clinic. The Core will specifically act as a focal point and resource to bring new ideas, technologies, interventions, and researchers into the UP-PDTC and the PDXNet. Second, the Pilot Projects and Trans-Network Core will prioritize and facilitate novel projects that can add to the translational capabilities of the PDXNet. Key criteria for project selection will include 1) high expected impact; 2) translational potential that may eventually be integrated into full projects within the UP-PDTC or PDXNet; 3) innovative ideas and approaches that generate new hypotheses and preliminary data; 4) collaborations to develop novel research and research tools, 5) high risk/high return projects that move basic science and/or clinical interventions and 6) development of tissue collections that address cancer disparities. Although the UP-PDTC will be a T-PDTC, we acknowledge and highly support the latter goal. Pilot project grants will be competitively financially supported by the Core budget and the PDX Core personnel will work with Pilot Project PI’s to develop application to the TransNetwork program and/or for specific R01 applications. Solicitations for Core projects are made within the University of Pennsylvania Abramson Cancer Center. Specific efforts will be made to recruit Pilot Project applicants from underrepresented minorities (URM), women, and individuals with disabilities. The UP-PDTC Administrative Core will assist in implementing a coordinated process for review, selection, and monitoring Pilot Projects, ensuring that UP-PDTC resources are used effectively to expand PDX modeling, interactions with the PDXNet and PDXNet research. The influx of research from new PDX modelers and investigators, or from those with expertise outside of the most common tumors, will foster innovative new directions and complement ongoing efforts in the UP-PDTC and PDXNet.

概括： UP-PDTC的飞行员项目和跨网络活动的目标集中在两个优先事项上。 首先，具有促进和支持具有高科学优点和创新的新飞行员项目的核心意愿意志 强烈影响PDX模型开发研究和/或具有转化为诊所的潜力 核心将指定作为带来新想法，技术，国际的焦点和资源 研究人员进入UP-PDTC和PDXNET。 优先考虑并促进可以增加PDXNET的翻译能力的新型项目 对于项目选择，将包括1）高期望的影响 在UP-PDTC或PDXNET中集成到完整的项目中； 3）创新的想法和方法 新的假设和初步数据； 4）开发新型研究和研究工具的合作 风险/高回报项目移动基础科学和/或临床干预措施以及6）组织的发展 解决癌症差异的收集。 高度支持后一个目标。 PDX核心人员工作工作工作工作工作PIPO PI PI旨在开发Transnetwork的应用 计划和/或特定的R01申请。 宾夕法尼亚州艾布拉姆森癌症中心将招募飞行员项目申请人 代表性不足的少数族裔（URM），妇女和残疾人行政管理 核心将协助实施协调的过程，以进行审查，选择和监视试点项目， 确保将UP-PDTC资源有效地用于扩展PDX建模，与PDXNET的交互 Andxnet研究。 在最常见的肿瘤之外的专业知识将促进创新的新方向和汇编 UP-PDTC和PDXNET中的主体。