High Sensitivity X-ray Detector for PET/CT

用于 PET/CT 的高灵敏度 X 射线探测器

• 批准号: 7121573
• 负责人: VIVEK V NAGARKAR
• 金额: $ 42.62万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121573
• 关键词: X ray; bioimaging /biomedical imaging; biomedical equipment development; charge coupled device camera; computed axial tomography; evaluation /testing; image enhancement; laboratory mouse; molecular /cellular imaging; phantom model; positron emission tomography; radiation detector; radiation dosage; radiobiology; scintillation counter; thermoluminescent radiation detector; X ray; bioimaging /biomedical imaging; biomedical equipment development; charge coupled device camera; computed axial tomography; evaluation /testing; image enhancement; laboratory mouse; molecular /cellular imaging; phantom model; positron emission tomography; radiation detector; radiation dosage; radiobiology; scintillation counter; thermoluminescent radiation detector

DESCRIPTION (provided by applicant): Dramatic advances in imaging technology, especially for small-animal imaging, have been an important driving force in establishing the field of molecular and genomic imaging. One of these new technologies, microPET, has demonstrated a tremendous potential in the study of small animal models, allowing the measurement of biological parameters and permitting in vivo imaging of transgene expression. Although rich in information content, interpretation of data for these studies can be very difficult due to the fact that PET images lack anatomical information. Thus, current trends are towards combining PET with CT so that the functional information from PET can be co-related to the anatomic information provided by CT. However, the use of this powerful combined modality is limited by the current x-ray detectors which provide excellent spatial resolution, but have low sensitivities and poor signal to noise ratios (SNR), resulting in a high dose to the animal. To improve the SNR and to reduce the x-ray dose to the animal, we propose to develop a novel x-ray detector for combined PET/CT systems. The detector will be based on a high efficiency scintillator coupled to a new imaging sensor that simultaneously provides high resolution, an internal avalanche gain, and a very low total noise. The system will allow for dramatic improvements in visualization, interpretation, and quantification of PET data using superior anatomical CT images obtained at a substantially reduced dose. The availability of a high-sensitivity, high-resolution, large area x-ray detector will allow development of new generation of combined small animal imagers, which provide a powerful tool for studies of such disease as cancer. As such, this detector will be of great interest to the pharmaceutical industry. In addition to the small animal imaging, the detector will have tremendous application potential in areas such as medical imaging, structural biology, nondestructive testing etc. The current market for x-ray detector is estimated to be in hundreds of millions of dollars, a significant fraction of which represents applications where proposed technology would be of great help.

描述（由申请人提供）： 成像技术的急剧进步，尤其是对于小动物成像，已经成为建立分子和基因组成像领域的重要驱动力。这些新技术之一Micropet在研究小动物模型的研究中表现出了巨大的潜力，可以测量生物学参数，并允许在体内成像转基因表达。尽管信息含量丰富，但由于宠物图像缺乏解剖信息，对这些研究的数据解释可能非常困难。因此，当前的趋势是将PET与CT结合在一起，因此PET的功能信息可以与CT提供的解剖学信息共同相关。但是，这种强大的组合方式的使用受到当前提供出色空间分辨率的当前X射线检测器的限制，但敏感性低，信号比（SNR）较差，从而对动物产生了高剂量。 为了改善SNR并减少对动物的X射线剂量，我们建议为合并的PET/CT系统开发一种新型的X射线检测器。该检测器将基于与新成像传感器相连的高效率闪烁体，该闪光灯同时提供了高分辨率，内部雪崩增益和非常低的总噪声。该系统将允许使用以大幅降低的剂量获得的出色解剖学CT图像来显着改善PET数据的可视化，解释和量化。高敏性，高分辨率，大面积X射线检测器的可用性将允许开发新一代的小动物成像仪，这为癌症等疾病提供了有力的工具。因此，该探测器将引起制药行业的极大兴趣。除了小动物成像外，检测器还将在医学成像，结构生物学，无损测试等领域具有巨大的应用潜力。估计X射线检测器的当前市场估计为数亿美元，这是一小部分，其中一小部分代表该技术在提议的技术中具有很大的帮助。