High Sensitivity X-ray Detector for PET/CT

用于 PET/CT 的高灵敏度 X 射线探测器

• 批准号: 7121573
• 负责人: VIVEK V NAGARKAR
• 金额: $ 42.62万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121573
• 关键词: X ray; bioimaging /biomedical imaging; biomedical equipment development; charge coupled device camera; computed axial tomography; evaluation /testing; image enhancement; laboratory mouse; molecular /cellular imaging; phantom model; positron emission tomography; radiation detector; radiation dosage; radiobiology; scintillation counter; thermoluminescent radiation detector

DESCRIPTION (provided by applicant): Dramatic advances in imaging technology, especially for small-animal imaging, have been an important driving force in establishing the field of molecular and genomic imaging. One of these new technologies, microPET, has demonstrated a tremendous potential in the study of small animal models, allowing the measurement of biological parameters and permitting in vivo imaging of transgene expression. Although rich in information content, interpretation of data for these studies can be very difficult due to the fact that PET images lack anatomical information. Thus, current trends are towards combining PET with CT so that the functional information from PET can be co-related to the anatomic information provided by CT. However, the use of this powerful combined modality is limited by the current x-ray detectors which provide excellent spatial resolution, but have low sensitivities and poor signal to noise ratios (SNR), resulting in a high dose to the animal. To improve the SNR and to reduce the x-ray dose to the animal, we propose to develop a novel x-ray detector for combined PET/CT systems. The detector will be based on a high efficiency scintillator coupled to a new imaging sensor that simultaneously provides high resolution, an internal avalanche gain, and a very low total noise. The system will allow for dramatic improvements in visualization, interpretation, and quantification of PET data using superior anatomical CT images obtained at a substantially reduced dose. The availability of a high-sensitivity, high-resolution, large area x-ray detector will allow development of new generation of combined small animal imagers, which provide a powerful tool for studies of such disease as cancer. As such, this detector will be of great interest to the pharmaceutical industry. In addition to the small animal imaging, the detector will have tremendous application potential in areas such as medical imaging, structural biology, nondestructive testing etc. The current market for x-ray detector is estimated to be in hundreds of millions of dollars, a significant fraction of which represents applications where proposed technology would be of great help.

描述（由申请人提供）： 成像技术，特别是小动物成像技术的巨大进步，一直是建立分子和基因组成像领域的重要驱动力。其中一项新技术 microPET 在小动物模型研究中展现出了巨大的潜力，可以测量生物参数并允许转基因表达的体内成像。尽管信息内容丰富，但由于 PET 图像缺乏解剖信息，解释这些研究的数据可能非常困难。因此，当前的趋势是将 PET 与 CT 相结合，以便 PET 提供的功能信息可以与 CT 提供的解剖信息相互关联。然而，这种强大的组合模式的使用受到当前 X 射线探测器的限制，这些探测器提供了出色的空间分辨率，但灵敏度较低，信噪比 (SNR) 较差，导致动物受到高剂量。 为了提高信噪比并减少对动物的 X 射线剂量，我们建议开发一种用于组合 PET/CT 系统的新型 X 射线探测器。该探测器将基于与新型成像传感器耦合的高效闪烁体，该传感器同时提供高分辨率、内部雪崩增益和极低的总噪声。该系统将使用在大幅降低剂量下获得的优质解剖 CT 图像，显着改进 PET 数据的可视化、解释和量化。高灵敏度、高分辨率、大面积 X 射线探测器的出现将有助于开发新一代组合式小动物成像仪，为癌症等疾病的研究提供强大的工具。因此，该检测器将引起制药行业的极大兴趣。除小动物成像外，该探测器在医学成像、结构生物学、无损检测等领域也将具有巨大的应用潜力。目前X射线探测器的市场规模预计达数亿美元，是一个重要的市场。其中一小部分代表所提出的技术将有很大帮助的应用。