Continuous Phoswich Detector for Molecular Imaging

用于分子成像的连续磷光探测器

基本信息

批准号：
7537072
负责人：
VIVEK V NAGARKAR
金额：
$ 18万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2010-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7537072
关键词：
Address Animals Area Arizona Biological Process Bite Cardiovascular system Collaborations Collimator Complex Data Data Analyses Deposition Depth Detection Development Devices Diagnosis Diagnostic radiologic examination Discipline of Nuclear Medicine Disease Disease model Evaluation Event Face Film Foundations Future Gamma Rays Goals Government Grant Growth Head Heart Heart Diseases Human Image Imaging Techniques Industry Ions Laboratory Animals Lanthanoid Series Elements Lead Letters Light Localized Malignant Neoplasms Measurement Measures Medical Imaging Methods Monitor Morphology Mus Noise Numbers Penetration Performance Persons Pharmaceutical Preparations Phase Photons Positron-Emission Tomography Process Property Protocols documentation Public Health Purpose Radial Radiation Radiation Monitoring Radioimmunoconjugate Radioisotopes Radiolabeled Rate Rattus Reporting Research Research Personnel Resolution Rewards Roentgen Rays Role Saints Salts Security Signal Transduction Source Staging Standards of Weights and Measures Structure System Techniques Technology Testing Therapeutic Intervention Thick Time Universities Vacuum Variant Width Work Writing X ray diffraction analysis X-Ray Computed Tomography X-Ray Diffraction absorption attenuation base cerous chloride concept cost cost effective data acquisition desire detector evaporation human disease improved in vivo instrumentation light emission molecular imaging monitoring device novel professor programs radiotracer reconstruction research study seal sensor single photon emission computed tomography thallium-doped sodium iodide tool tumor

项目摘要

DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) imaging systems used in Nuclear Medicine can suffer from loss of spatial resolution due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- interaction (DOI) determination would be an important advance. Previous attempts were made to develop DOI scintillators for PET, but all of them had significant performance limitations. The goal of the proposed Phase I research is to demonstrate the feasibility of developing a novel DOI scintillator in which the decay time of the light emission varies continuously with depth. The material processing techniques will be used to form a continuous phoswich detector, which will create a structure where the decay time of the light emission varies continuously with depth. Our approach is likely applicable to a number of new scintillators that are actively under development because of their superior properties, as well as to other scintillators known to show dramatic variations in decay times with dopant concentration. A number of most likely candidates will be initially investigated. Scintillator fabrication and initial characterization will be performed at RMD, and tests pertinent to molecular imaging will be performed at our collaborator's facilities at the University of Arizona. Molecular imaging techniques are well suited for imaging radiolabeled antibodies and other substances that can be used to localize and characterize tumors, and are well suited to the development of new radiolabeled agents for diagnosing and treating diseases in humans. The development of this detector will significantly improve the resolution and sensitivity with which measurements can be made. In turn, this will encourage the development of superior drugs and technologies to diagnose, stage and treat to curtail the progression of and even cure certain cancers, diseases of the heart and disorders of the circulatory system. Outside medical imaging, the proposed development will have widespread applications in industrial radiography, nondestructive evaluations, homeland security, and advanced imaging systems. PUBLIC HEALTH RELEVANCE: Positron Emission Tomography (PET) imaging systems used in nuclear medicine can suffer from loss of spatial resolution due to parallax effects, called radial elongation. A scintillation detector that allows depth-of- interaction (DOI) determination would be an important advance. Previous attempts were made to develop DOI scintillators for PET, but all of them had significant performance limitations. The proposed research will demonstrate the feasibility of developing a novel DOI scintillator in which the decay time of the light emission varies continuously with depth. The successful completion of the research will lead to widespread applications in medical imaging, industrial radiography, nondestructive evaluations, homeland security, and advanced imaging systems.

描述（由申请人提供）：核医学中使用的正电子发射断层扫描（PET）成像系统可能会因视差效应（称为径向伸长）而遭受空间分辨率的损失。允许确定相互作用深度（DOI）的闪烁探测器将是一个重要的进步。之前曾尝试开发用于 PET 的 DOI 闪烁体，但它们都具有显着的性能限制。拟议第一阶段研究的目标是证明开发一种新型 DOI 闪烁体的可行性，其中光发射的衰减时间随深度连续变化。材料加工技术将用于形成连续磷光探测器，这将创建一种光发射的衰减时间随深度连续变化的结构。我们的方法可能适用于许多由于其优越性能而正在积极开发的新型闪烁体，以及已知的随着掺杂剂浓度而显示出衰减时间显着变化的其他闪烁体。一些最有可能的候选人将被初步调查。闪烁体的制造和初始表征将在 RMD 进行，与分子成像相关的测试将在我们合作者位于亚利桑那大学的设施中进行。分子成像技术非常适合对放射性标记抗体和其他可用于定位和表征肿瘤的物质进行成像，并且非常适合开发用于诊断和治疗人类疾病的新型放射性标记药物。该探测器的开发将显着提高测量的分辨率和灵敏度。反过来，这将鼓励开发先进的药物和技术来诊断、分期和治疗，以遏制甚至治愈某些癌症、心脏疾病和循环系统疾病。除了医学成像之外，拟议的开发将在工业放射线照相、无损评估、国土安全和先进成像系统中广泛应用。公共健康相关性：核医学中使用的正电子发射断层扫描 (PET) 成像系统可能会因视差效应（称为径向伸长）而导致空间分辨率损失。允许确定相互作用深度（DOI）的闪烁探测器将是一个重要的进步。之前曾尝试开发用于 PET 的 DOI 闪烁体，但它们都具有显着的性能限制。拟议的研究将证明开发一种新型 DOI 闪烁体的可行性，其中光发射的衰减时间随深度连续变化。该研究的成功完成将导致其在医学成像、工业射线照相、无损评估、国土安全和先进成像系统等领域的广泛应用。