PerkinElmer IVIS Spectrum CT

PerkinElmer IVIS 光谱 CT

基本信息

批准号：
8826454
负责人：
Judy Drazba
金额：
$ 59.97万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-13 至 2016-02-12
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The Imaging Core of the Cleveland Clinic Lerner Research Institute (LRI) and a group of sixteen investigators (12 NIH-funded) request funds to purchase a PerkinElmer IVIS Spectrum CT. It will be placed in the Small-Animal Imaging section of the well-established Imaging Core where it will be broadly used in the pre-clinical and translational medicine research program at Cleveland Clinic. In its twenty years the Core has provided leading-edge imaging equipment and expertise for the Cleveland Clinic research community. It is a strong and successful Core in a significant research facility. As the calculatio of the costs and benefits of research funding grows more acute, investigators are seeking a more immediate pathway from basic biomedical research to clinical application - often with wider and more frequent reliance on animal model studies. The instrument here requested is fundamental to such research, and essential to the projects presented herein. This integrated, multi-modal system will provide us a new and much-needed level of imaging capability and flexibility, including the possibility of Computed Tomography (an option previously available to very few researchers on a 9-year-old GE Explorer Locus RS that is now failing and is officially obsolete). The improved sensitivity, resolution, and three-dimensional quantitative imaging of the IVIS Spectrum CT will allow for a broad range of applications envisioned by the studies included here: for example, the impact of the gut microbiome on cardiovascular disease or the factors that modulate glioblastoma development, progression, and response to therapy. The need of the included investigators for this instrument is further underscored by the decision of our Institute to enhance animal health and experimental safety by creating a mouse barrier facility. This is a costly project, already underway. It significantly affects our investigators' experiments, since they will have to take place inside the barrier. Because of this, the new facility will include an Imaging Suite-with a room designated specifically for this instrument. The new system will be under the Imaging Core's management, assuring its supervision and support by a skilled staff. Dr. Judith Drazba, Core Director, has over thirty years' experience in biomedical imaging, twenty of them running this facility. Dr. Dolores Hambardzumyan, co-PI on this grant, has ten years of intensive experience in a full range of small animal imaging. Other members of the Imaging Core staff will assist with user training, and equipment troubleshooting and maintenance. Finally, the LRI has a long history of strong support for centralized facilities and will continue its commitment to the Imaging Core by providing funds for salary support, service contracts, and infrastructure.

描述（由申请人提供）：克利夫兰诊所勒纳研究所 (LRI) 的成像核心和由 16 名研究人员（12 名 NIH 资助）组成的小组请求资金购买一台 PerkinElmer IVIS Spectrum CT，并将其放置在 Small- 中。成熟的成像核心的动物成像部分将广泛应用于克利夫兰诊所的临床前和转化医学研究项目，该核心在二十年来提供了领先的成像技术。它是克利夫兰诊所研究界强大而成功的核心。随着研究经费的成本和收益的计算变得更加尖锐，研究人员正在寻求从基础生物医学研究到更直接的途径。临床应用 - 通常更广泛和更频繁地依赖动物模型研究，这里要求的仪器是此类研究的基础，并且对于本文提出的项目至关重要，这种集成的多模式系统将为我们提供一个新的、急需的水平。成像能力和灵活性，包括计算机断层扫描的可能性（以前很少有研究人员在使用了 9 年的 GE Explorer Locus RS 上使用该选项，该选项现已失效并已正式过时）IVIS Spectrum CT 改进的灵敏度、分辨率和三维定量成像将允许这里包括的研究设想了广泛的应用：例如，肠道微生物组对心血管疾病的影响或调节胶质母细胞瘤发生、进展和治疗反应的因素。所包括的研究人员对该仪器的需求进一步增加。我们研究所决定通过建立小鼠屏障设施来加强动物健康和实验安全，这是一个已经在进行的耗资巨大的项目，因为它们必须在屏障内进行。其中，新设施将包括一个成像套件，其中有一个专门为该仪器指定的房间。新系统将由成像核心管理，确保核心主任 Judith Drazba 博士在生物医学成像方面拥有 30 多年的经验，其中有 20 名负责管理该设施的人员负责监督和支持。此项资助的共同 PI 在全方位小动物成像方面拥有十年的丰富经验，成像核心人员的其他成员将协助用户培训、设备故障排除和维护。长期以来一直对集中设施提供强有力的支持，并将通过为薪资支持、服务合同和基础设施提供资金，继续致力于成像核心。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells.

DOI：
10.15252/emmm.202012291
发表时间：
2020-12-07
期刊：
EMBO molecular medicine
影响因子：
11.1
作者：
Tao W;Zhang A;Zhai K;Huang Z;Huang H;Zhou W;Huang Q;Fang X;Prager BC;Wang X;Wu Q;Sloan AE;Ahluwalia MS;Lathia JD;Yu JS;Rich JN;Bao S
通讯作者：
Bao S

Novel INHAT repressor drives glioblastoma growth by promoting ribosomal DNA transcription in glioma stem cells.

新型 INHAT 阻遏蛋白通过促进神经胶质瘤干细胞中的核糖体 DNA 转录来驱动胶质母细胞瘤生长。

DOI：
10.1093/neuonc/noac272
发表时间：
2023
期刊：
Neuro-oncology
影响因子：
15.9
作者：
Tao,Weiwei;Lei,Hong;Luo,Wenlong;Huang,Zhi;Ling,Peng;Guo,Mengyue;Wan,Lihao;Zhai,Kui;Huang,Qian;Wu,Qiulian;Xu,Shutong;Zeng,Liang;Wang,Xiuxing;Dong,Zhiqiang;Rich,JeremyN;Bao,Shideng
通讯作者：
Bao,Shideng

Cathepsin K-targeted sub-micron particles for regenerative repair of vascular elastic matrix.

DOI：
10.1016/j.actbio.2017.01.032
发表时间：
2017-04-01
期刊：
Acta biomaterialia
影响因子：
9.7
作者：
Jennewine B;Fox J;Ramamurthi A
通讯作者：
Ramamurthi A

Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination.

DOI：
10.1084/jem.20151673
发表时间：
2017-01
期刊：
The Journal of experimental medicine
影响因子：
0
作者：
Fang X;Zhou W;Wu Q;Huang Z;Shi Y;Yang K;Chen C;Xie Q;Mack SC;Wang X;Carcaboso AM;Sloan AE;Ouyang G;McLendon RE;Bian XW;Rich JN;Bao S
通讯作者：
Bao S

Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells.