Impact of Trauma Exposure on Critical Periods in Brain Development and Fear Processing in Children

创伤暴露对儿童大脑发育和恐惧处理关键期的影响

基本信息

批准号：
10024074
负责人：
Tanja Jovanovic
金额：
$ 65.99万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10024074
关键词：
10 year old 11 year old 9 year old Abuse Reporting Acute Address Adolescence Adolescent Adult Adverse event Affect African American Age Amygdaloid structure Anxiety Anxiety Disorders Area Arousal Base of the Brain Brain Child Child Abuse Childhood Clinical Data Data Development Diagnosis Discrimination Environment Epidemic Event Exposure to Family Female Fright Functional disorder Future Hippocampus (Brain)Incidence Study Intervention Knowledge Laboratories Life Longitudinal Studies Low income MRI Scans Mental Depression Mental Health Mental disorders Methods Modeling Negative Valence Neurobiology Outcome Patient Self-Report Pattern Personality Disorders Phenotype Physiology Population Positioning Attribute Post-Traumatic Stress Disorders Prefrontal Cortex Prevalence Psychopathology Reporting Research Research Domain Criteria Rest Risk Risk Factors Safety Sampling Scanning Schizophrenia Sex Differences Signal Transduction Startle Reaction Structure Substance abuse problem Symptoms System T2 weighted imaging Trauma Urban Population Visit adverse outcome base clinically relevant cohort conditioned fear critical period dimensional analysis follow-up high risk inner city longitudinal design male maltreatment myelination neural circuit neurodevelopment neuroimaging pediatric trauma prepuberty prospective recruit relating to nervous system response sex trauma exposure traumatic event violence exposure

项目摘要

SUMMARY Childhood trauma exposure constitutes a major risk factor for subsequent psychopathology, including depression, posttraumatic stress disorder, substance abuse, personality disorders, and schizophrenia. Violence exposure in low-income, urban populations can occur early in life, increasing risk for trauma exposure in children living in inner-city areas. While it is shown that early adverse experiences affect brain activation and connectivity as well as fear physiology during development in children, the mechanisms of these effects on the brain are not clearly understood. Very few studies have captured the effects of ongoing trauma during development, as most are based on retrospective data. The proposed longitudinal study is well-positioned to address this gap in knowledge given our recruitment from a high trauma risk population. The proposed research will combine neuroimaging and fear physiology methods to examine critical periods for trauma-related correlates of brain development. Recruitment of male and female children will allow for exploratory analyses of sex differences during development. Retrospective research on trauma exposure and neural development suggest that ages 9 through 11 represent particularly sensitive periods for fear-relevant neurobiology. In order to target this critical period, 9-year-old children will be recruited from the Grady Trauma Project in inner-city Atlanta, composed primarily of low-income, African American families and followed prospectively for two years. Trauma exposure and startle will be assessed every six months between ages 9 and 11, in order to assess the critical period for trauma exposure. Brain structure and function will be assessed every year, at years 9, 10, and 11. In our previous studies, we have found that the degree of trauma exposure significantly increases between 9 and 11 years of age. The unique prospective longitudinal design will allow for analysis of the effects of both pre-existing trauma and new trauma exposure on the neurobiological phenotypes.

概括儿童创伤暴露构成了随后的心理病理学的主要危险因素，包括抑郁症，创伤后应激障碍，药物滥用，人格障碍，和精神分裂症。低收入的暴力暴露，城市人口可能会在生命的早期发生，增加城市内部儿童的创伤风险增加。虽然证明早期不良经历会影响大脑的激活和连通性以及恐惧生理在儿童发育期间，这些对大脑的影响的机制尚不清楚理解。很少有研究捕获了开发过程中持续创伤的影响，因为大多数是基于回顾性数据。拟议的纵向研究非常适合考虑到我们从高创伤风险人群中招募的知识差距。这拟议的研究将结合神经影像学和恐惧生理方法，以检查关键与创伤相关的脑发育相关时期。招募男性和女性儿童将允许对发展过程中的性别差异进行探索性分析。关于创伤和神经发育的回顾性研究表明，年龄9 通过11个代表了与恐惧相关的神经生物学特别敏感的时期。为了针对这个关键时期，将从Grady创伤项目中招募9岁儿童亚特兰大市中心，主要由低收入的非裔美国人家庭组成，并遵循前瞻性两年。每六个月评估一次创伤和惊吓在9至11岁之间，以评估创伤暴露的关键时期。脑结构和功能每年将在9、10和11年度进行评估。在我们以前的研究，我们发现创伤程度显着增加了9个和11岁。独特的前瞻性纵向设计将允许分析现有创伤和新创伤暴露对神经生物学的影响表型。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Human fear neurobiology reimagined: Can brain-derived biotypes predict fear-based disorders after trauma?

DOI：
10.1016/j.neubiorev.2022.104988
发表时间：
2022-12-13
期刊：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
影响因子：
8.2
作者：
McClellan, John;Jovanovic, Tanja
通讯作者：
Jovanovic, Tanja

Neural Impacts of Stigma, Racism, and Discrimination.

耻辱、种族主义和歧视对神经的影响。

DOI：
10.1016/j.bpsc.2022.06.012
发表时间：
2022
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
0
作者：
Grasser,LanaRuvolo;Jovanovic,Tanja
通讯作者：
Jovanovic,Tanja

Evolving Use of fMRI in Medicare Beneficiaries.

功能磁共振成像在医疗保险受益人中的不断发展。

DOI：
10.3174/ajnr.a6845
发表时间：
2020
期刊：
AJNR. American journal of neuroradiology
影响因子：
0
作者：
Asnafi,S;Duszak,R;Hemingway,JM;Hughes,DR;Allen,JW
通讯作者：
Allen,JW

Safety learning during development: Implications for development of psychopathology.

DOI：
10.1016/j.bbr.2021.113297
发表时间：
2021-06-25
期刊：
Behavioural brain research
影响因子：
2.7
作者：
Grasser LR;Jovanovic T
通讯作者：
Jovanovic T

Associations between children's trauma-related sequelae and skin conductance captured through mobile technology.

DOI：
10.1016/j.brat.2022.104036
发表时间：
2022-03
期刊：
Behaviour research and therapy
影响因子：
4.1
作者：
Wiltshire CN;Wanna CP;Stenson AF;Minton ST;Reda MH;Davie WM;Hinrichs R;Winters S;France JM;Jovanovic T
通讯作者：
Jovanovic T