Dual Mode, Hand-held Intraoperative Imager

双模式手持式术中成像仪

• 批准号: 8551648
• 负责人: VIVEK V NAGARKAR
• 金额: $ 14.69万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-26 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8551648
• 关键词: Animals; Area; Background Radiation; Beds; Beta Particle; Biopsy; Cancerous; Charge; Chemotherapy-Oncologic Procedure; Clinical; Data; Deposition; Development; Devices; Diagnostic; Discrimination; Electronics; Endometrial; Evaluation; Event; Excision; Feedback; Gamma Rays; Goals; Government; Hand; Head; Hybrids; Image; Imaging Device; Inpatients; Investigation; Lead; Lesion; Location; Malignant - descriptor; Marketing; Methods; Metric; Modeling; Motivation; Operative Surgical Procedures; Oryctolagus cuniculus; Patients; Performance; Persons; Phase; Physiologic pulse; Positioning Attribute; Positron; Positron-Emission Tomography; Protocols documentation; Radiation; Radio; Radioisotopes; Recovery; Reporting; Research; Resolution; Shapes; Software Design; Source; Specificity; Surgeon; Surgical incisions; Surveys; Technology; Testing; Therapeutic; Time; Tissues; Tracer; Writing; commercialization; design; detector; engineering design; hospital utilization; imaging probe; improved; meetings; photomultiplier; prototype; research study; response; seal; sensor; solid state; technology development; tool; tumor; tumor growth; uptake; vapor

DESCRIPTION (provided by applicant): Radionuclide-guided intraoperative probes increase the specificity of tissue biopsies, enable minimal- access incisions, reduce inpatient hospital utilization, and contribute to improved patient recovery. At present, most such probes on the market are non-imaging, and provide no ancillary information of surveyed areas, such as clear delineations of malignant tissues. Our goal is to develop a revolutionary new imaging probe, the Imaging Beta ProbeTM (IBPTM), intended for rapid localization of lesions by sensing gamma rays, followed by real-time high-sensitivity imaging of short-range beta particles or positrons. This ergonomically designed probe will be small and easy to use during surgery, and is made possible by the recent development of position- sensitive solid-state photomultiplier (PS-SSPM) and hybrid scintillation technologies at RMD. The probe will provide continuous real-time audio and/or video feedback of emissions from surveyed areas to the surgeon for rapid and accurate delineation and precise excision of lesions, with minimal sacrifice of surrounding healthy tissue. After excision of suspect tissue, the IBPTM will allow the surgeon to check the tumor bed and margins for any remaining cancerous and pre-cancerous tissue, fine tumors or other tissues (e.g., endometrial) capable of uptake of the administered tracer, that are otherwise obscured by background radiation. Our motivation in pursuing our proposed Imaging Beta Probe design is that it will provide the first radical change in probe technology in decades and, most importantly, significant improvement in and broadening of the clinical capabilities of intraoperative and external diagnostic probes. Development of this technology provides an imaging tool for surgeons to detect PET-positive lesions intraoperatively, which will advance their ability to confirm data provided by PET scans with biopsy material. Furthermore, these tools may allow a surgeon to perform a PET-guided exploration and therapeutic excision of a small lesion that would otherwise be undiscovered by conventional exploration or treated by a harsh empiric regimen of chemotherapy or radiation.

描述（由申请人提供）：放射性核素引导的术中探针提高了组织活检的特异性，实现了最小切口，减少了住院患者的利用率，并有助于改善患者的康复。目前，市场上的大多数此类探头都是非成像的，并且不提供所检查区域的辅助信息，例如清晰描绘恶性组织。我们的目标是开发一种革命性的新型成像探针，成像 Beta 探针 (IBPTM)，旨在通过感测伽马射线快速定位病变，然后对短程 β 粒子或正电子进行实时高灵敏度成像。这种符合人体工程学设计的探头体积小，易于在手术期间使用，并且是通过 RMD 最近开发的位置敏感固态光电倍增管 (PS-SSPM) 和混合闪烁技术而实现的。该探头将向外科医生提供来自测量区域的发射的连续实时音频和/或视频反馈，以便快速准确地描绘和精确切除病灶，同时最大限度地减少周围健康组织的牺牲。切除可疑组织后，IBPTM 将允许外科医生检查肿瘤床和边缘是否有任何剩余的癌性和癌前组织、细小肿瘤或能够吸收所施用示踪剂的其他组织（例如子宫内膜），否则这些组织将被切除。被背景辐射遮蔽。 我们追求我们提出的成像 Beta 探针设计的动机是，它将为探针技术带来几十年来的第一次根本性变革，最重要的是， 显着改善和扩大术中和外部诊断探针的临床能力。这项技术的开发为外科医生提供了一种成像工具，可以在术中检测 PET 阳性病变，这将提高他们利用活检材料确认 PET 扫描提供的数据的能力。此外，这些工具可以让外科医生对小病变进行 PET 引导探查和治疗性切除，否则传统探查无法发现这些病变，或者通过严格的化疗或放疗经验性方案无法治疗这些病变。