Dual Mode, Hand-held Intraoperative Imager

双模式手持式术中成像仪

基本信息

批准号：
8455692
负责人：
VIVEK V NAGARKAR
金额：
$ 14.9万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-26 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8455692
关键词：
Animals Area Background Radiation Beds Beta Particle Biopsy Cancerous Charge Chemotherapy-Oncologic Procedure Clinical Data Deposition Development Devices Diagnostic Discrimination Electronics Endometrial Evaluation Event Excision Feedback Gamma Rays Goals Government Hand Head Hybrids Image Imaging Device Inpatients Investigation Lead Lesion Location Malignant - descriptor Marketing Methods Metric Modeling Motivation Operative Surgical Procedures Oryctolagus cuniculus Patients Performance Persons Phase Physiologic pulse Positioning Attribute Positron Positron-Emission Tomography Protocols documentation Radiation Radio Radioisotopes Recovery Reporting Research Resolution Shapes Software Design Source Specificity Surgeon Surgical incisions Surveys Technology Testing Therapeutic Time Tissues Tracer Writing commercialization design detector engineering design hospital utilization imaging probe improved meetings photomultiplier prototype research study response seal sensor solid state technology development tool tumor tumor growth uptake vapor

项目摘要

DESCRIPTION (provided by applicant): Radionuclide-guided intraoperative probes increase the specificity of tissue biopsies, enable minimal- access incisions, reduce inpatient hospital utilization, and contribute to improved patient recovery. At present, most such probes on the market are non-imaging, and provide no ancillary information of surveyed areas, such as clear delineations of malignant tissues. Our goal is to develop a revolutionary new imaging probe, the Imaging Beta ProbeTM (IBPTM), intended for rapid localization of lesions by sensing gamma rays, followed by real-time high-sensitivity imaging of short-range beta particles or positrons. This ergonomically designed probe will be small and easy to use during surgery, and is made possible by the recent development of position- sensitive solid-state photomultiplier (PS-SSPM) and hybrid scintillation technologies at RMD. The probe will provide continuous real-time audio and/or video feedback of emissions from surveyed areas to the surgeon for rapid and accurate delineation and precise excision of lesions, with minimal sacrifice of surrounding healthy tissue. After excision of suspect tissue, the IBPTM will allow the surgeon to check the tumor bed and margins for any remaining cancerous and pre-cancerous tissue, fine tumors or other tissues (e.g., endometrial) capable of uptake of the administered tracer, that are otherwise obscured by background radiation. Our motivation in pursuing our proposed Imaging Beta Probe design is that it will provide the first radical change in probe technology in decades and, most importantly, significant improvement in and broadening of the clinical capabilities of intraoperative and external diagnostic probes. Development of this technology provides an imaging tool for surgeons to detect PET-positive lesions intraoperatively, which will advance their ability to confirm data provided by PET scans with biopsy material. Furthermore, these tools may allow a surgeon to perform a PET-guided exploration and therapeutic excision of a small lesion that would otherwise be undiscovered by conventional exploration or treated by a harsh empiric regimen of chemotherapy or radiation. PUBLIC HEALTH RELEVANCE: Radionuclide-guided intraoperative probes increase the specificity of tissue biopsies, enable minimal- access incisions, reduce inpatient hospital utilization, and contribute to improved patient recovery. Our goal is to develop a revolutionary new imaging probe, the Imaging Beta ProbeTM (IBPTM), intended for rapid localization of lesions by sensing gamma rays, followed by real-time high-sensitivity imaging of short-range beta particles or positrons. Development of this technology provides an imaging tool for surgeons to detect PET-positive lesions intraoperatively, which will advance their ability to confirm data provided by PET scans with biopsy material.

描述（由申请人提供）：放射性核素引导的术中探针增加了组织活检的特异性，实现最小的入口切口，减少住院医院的利用，并有助于改善患者的康复。目前，市场上的大多数此类探针都是非成像的，并且没有提供被调查区域的辅助信息，例如对恶性组织的明确描述。我们的目标是开发一种革命性的新成像探针，即成像beta探针（IBPTM），该探针旨在通过感测伽玛射线来快速定位病变，然后是对短距离β颗粒或正电子的实时高敏性成像。该符合人体工程学设计的探针在手术过程中将很小且易于使用，并且由于最近在RMD的位置敏感固态光电培养体（PS-SSPM）和混合闪烁技术而成为可能。该探针将提供从调查区域到外科医生的排放量的连续实时音频和/或视频反馈，以快速准确地描述和精确切除病变，而周围健康组织的牺牲很小。切除可疑组织后，IBPTM将使外科医生能够检查肿瘤床和边缘，以了解能够吸收施用的截止器的任何剩余的癌性和癌性组织，细肿瘤或其他组织（例如子宫内膜），这些截止器否则会被背景辐射遮盖。我们追求提出的成像beta探针设计的动机是，它将在数十年来提供探针技术的首次彻底改变，最重要的是，术中和外部诊断探针的临床能力的显着改善和扩大。该技术的开发为外科医生提供了一种成像工具，可以在术中检测宠物阳性病变，这将提高其确认具有活检材料PET扫描提供的数据的能力。此外，这些工具可能会使外科医生可以对小病变进行宠物引导的探索和治疗切除，否则该病变将通过常规勘探或通过化学疗法或放射线的苛刻的经验丰富的治疗方法未被发现。公共卫生相关性：放射性核素引导的术中探针增加组织活检的特异性，使最小的入口切口，减少住院医院的利用，并有助于改善患者的康复。我们的目标是开发一种革命性的新成像探针，即成像beta探针（IBPTM），该探针旨在通过感测伽玛射线来快速定位病变，然后是对短距离β颗粒或正电子的实时高敏性成像。该技术的开发为外科医生提供了一种成像工具，可以在术中检测宠物阳性病变，这将提高其确认具有活检材料PET扫描提供的数据的能力。