Internal-gain CMOS APS Camera for SPECT Imaging of Small Animals

用于小动物 SPECT 成像的内增益 CMOS APS 相机

• 批准号: 7110599
• 负责人: JAMES F CHRISTIAN
• 金额: $ 15.99万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110599
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; nuclear medicine; scintillation cameras; single photon emission computed tomography

DESCRIPTION (provided by applicant): Nuclear medicine techniques such as SPECT and PET are powerful tools for functional imaging of biological processes in vivo. Recently, there have been significant advances in development of human disease models in small animals. A critical advantage of SPECT and PET is that they allow functional information to be obtained non-invasively, so each animal can serve as its own control in studies with a longitudinal design. The main barriers to using nuclear medicine in studies of laboratory animals have traditionally been poor spatial-resolution, cost and accessibility. Clinical radionuclide systems are not suitable for small animal research. This work investigates the construction of a high spatial-resolution SPECT detector composed of a Csl (Tl- doped) scintillation array and an aligned, pitch-matched CMOS camera chip. The CMOS-camera chip integrates the pixel-level readout components with the internal-gain CMOS-APD pixels in a monolithic device. This technology combines the high-gain, high-bandwidth detection capabilities of APD detectors with the high-spatial resolution, high-pixel count, and low cost of CMOS active-pixel-sensor camera chips. The design and fabrication of the CMOS camera connected to a pitch-matched scintillation array represent the major milestones. In summary, we will advance CMOS imaging technology to produce an application- specific camera for small-animal SPECT imaging.

描述（由申请人提供）：SPECT和PET等核医学技术是体内生物过程功能成像的强大工具。最近，小动物的人类疾病模型的发展取得了重大进展。 SPECT和PET的关键优势是它们允许非侵入性获得功能信息，因此每种动物都可以作为其纵向设计的研究中的控制。传统上，在实验动物研究中使用核医学的主要障碍是空间分辨率较差，成本和可及性。临床放射性核素系统不适合小型动物研究。这项工作研究了由CSL（TL-oppoped）闪烁阵列和对齐的，俯仰匹配的CMOS摄像头芯片组成的高空间分辨率检测器的构建。 CMOS-CAMERA芯片将像素级读数组件与整体设备中的内部增益CMOS-APD像素集成在一起。该技术结合了APD检测器的高增强，高带宽检测能力，以及高空间分辨率，高像素计数和CMOS Active像素传感器相机芯片的低成本。连接到音高匹配的闪烁阵列的CMOS摄像头的设计和制造代表了主要里程碑。总而言之，我们将推进CMOS成像技术，以生产用于小动物SPECT成像的应用程序摄像头。