Device for Measuring Capillary Blood Flow and the Onset of Shock

测量毛细血管血流量和休克发生的装置

• 批准号: 8646183
• 负责人: JAMES F CHRISTIAN
• 金额: $ 49.74万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8646183
• 关键词: Accident and Emergency department; Acetylene; Algorithms; Blood; Blood Cells; Blood Flow Velocity; Blood Pressure; Blood capillaries; Blood flow; Cardiac Output; Cardiovascular system; Cause of Death; Cessation of life; Characteristics; Clinic; Clinical; Collaborations; Critical Care; Data; Development; Devices; Diffuse; Failure; Family suidae; Funding; Goals; Health; Heart Rate; Hemorrhage; Hemorrhagic Shock; Hospitals; Hour; Human; Hypoxia; Lead; Learning; Life; Lighting; Lower Body Negative Pressure; Measurement; Measures; Methods; Military Personnel; Modeling; Monitor; Motion; Operative Surgical Procedures; Optics; Organ; Organ failure; Patients; Perfusion; Phase; Physiologic Monitoring; Physiological; Predictive Value; Presyncopes; Property; Protocols documentation; Pulse Pressure; Radiation Monitoring; Reporting; Sepsis; Shock; Skin; Spectrum Analysis; Spinal; Stroke Volume; System; Testing; Time; Tissues; Trauma; Ultrasonography; Variant; Work; absorption; base; capillary; capillary bed; design; heart rate variability; improved; instrument; light scattering; meetings; monitoring device; mortality; peripheral blood; pressure; programs; research clinical testing; sensor; trauma centers; uptake; volunteer

DESCRIPTION (provided by applicant): Hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The long-term goal of this proposal, a collaboration between Radiation Monitoring Devices and the Mayo Clinic, is to develop a sensor patch (CBFM) that attaches to a patient's skin and continuously monitors capillary blood flow and predicts the onset of hemorrhagic shock. The sensor is based upon diffuse correlation spectroscopy (DCS). DCS measures fluctuations in near-infrared light scattering of blood cell motion in capillaries. DCS extracts th characteristic time constants due to mean blood flow velocity. The aims of the proposal are: 1. Integrate DCS system with physiological monitors, 2. Perform definitive measurements using the human lower body negative pressure (LBNP) model for hemorrhage. 3. Analyze DCS and physiological data and answer the following questions: Is normalization of subject-to-subject variation possible? Is subject-to-subject variability reduced by DRS-based determination of tissue scattering and absorbance properties? Is predictive value improved by addition of vital parameters and if so, what is the "best" approach to multiparametric "smart" algorithms? Is predictive value improved by measuring the change in τ with progressive bleed? 4. Perform LBNP studies under the US Army LBNP pressure to failure (presyncope) protocol. 5. Test the CBFM in a clinical setting during high-blood loss, human spinal surgery. 6. Complete all reports

描述（由申请人提供）：失血性休克是急诊科和创伤中心死亡的主要原因。目前，尚无临床上可接受的定量监测方法来监测因毛细血管血流量减少而导致的失血性休克死亡。辐射监测设备公司和梅奥诊所合作提出的这项提案的长期目标是开发一种传感器贴片 (CBFM)，该传感器附着在患者的皮肤上，持续监测毛细血管血流并预测失血性休克的发生。该传感器基于漫射相关光谱 (DCS) 测量毛细血管中血细胞运动的近红外光散射的波动。该提案的目的是：1. 将 DCS 系统与生理监测仪集成，2. 使用人体下半身负压进行明确的测量。 3. 分析 DCS 和生理数据并回答以下问题：是否可以通过基于 DRS 的组织散射和吸光度特性测定来减少受试者之间的变异性？ ? 通过添加重要参数是否可以提高预测值？如果是，多参数“智能”算法的“最佳”方法是什么？通过测量渐进式出血的 τ 变化是否可以提高预测值？ 4. 根据美国陆军 LBNP 压力衰竭（晕厥先兆）方案进行 LBNP 研究。 5. 在高失血人体脊柱手术期间在临床环境中测试 CBFM。