NearlR Photon-counting Camera for Optical Tomography

用于光学断层扫描的近红外光子计数相机

• 批准号: 6642995
• 负责人: JAMES F CHRISTIAN
• 金额: $ 10万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642995
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; digital imaging; image enhancement; image processing; infrared radiation; neoplasm /cancer diagnosis; optics; photoconduction; tomography

DESCRIPTION (provided by applicant): Early detection and routine clinical screening represent the first line of defense for preventing fatalities from cancer, a disease, which claimed 551,833, lives in the U.S. during the year 2000. Significant advances have been made in the medical imaging of tumors; however, many of these techniques are too expensive to be implemented for routine screening. Diffuse optical tomography (DOT) promises to provide a low-cost method for routine, non-invasive cancer screening. Unfortunately, the absence of appropriate imaging technologies for the high-frequency modulation techniques employed by DOT severely limits the spatial resolution and constrains the diagnostic value of DOT. This program resolves these limitations by developing a fully integrated, nearlR digital camera chip, which is an application specific integrated circuit (ASIC), that counts photons using Geiger avalanche photodiodes. This all-digital, CMOS (complementary-symmetry metal-oxide-semiconductor) imaging technology fulfills the demanding requirements for providing high-resolution DOT images. In Phase I, we will explore appropriate fabrication architectures for the ASIC and fabricate prototype pixel elements, along with the critical circuit components needed to support the pixel element. We will test the prototype devices and compare their measured performance to the initial design specifications.

描述（由申请人提供）： 早期检测和常规临床筛查是预防癌症死亡的第一道防线，2000 年，癌症在美国夺走了 551,833 人的生命。然而，其中许多技术过于昂贵，无法用于常规筛查。漫反射光学断层扫描 (DOT) 有望为常规、非侵入性癌症筛查提供一种低成本方法。不幸的是，DOT 采用的高频调制技术缺乏适当的成像技术，严重限制了 DOT 的空间分辨率并限制了 DOT 的诊断价值。 该计划通过开发完全集成的近红外数码相机芯片解决了这些限制，该芯片是一种专用集成电路 (ASIC)，可使用盖革雪崩光电二极管对光子进行计数。这种全数字 CMOS（互补对称金属氧化物半导体）成像技术满足提供高分辨率点图像的严格要求。在第一阶段，我们将探索 ASIC 的适当制造架构，并制造原型像素元件，以及支持像素元件所需的关键电路组件。我们将测试原型设备并将其测量性能与初始设计规格进行比较。