NearlR Photon-counting Camera for Optical Tomography

用于光学断层扫描的近红外光子计数相机

• 批准号: 6642995
• 负责人: JAMES F CHRISTIAN
• 金额: $ 10万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6642995
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; digital imaging; image enhancement; image processing; infrared radiation; neoplasm /cancer diagnosis; optics; photoconduction; tomography

DESCRIPTION (provided by applicant): Early detection and routine clinical screening represent the first line of defense for preventing fatalities from cancer, a disease, which claimed 551,833, lives in the U.S. during the year 2000. Significant advances have been made in the medical imaging of tumors; however, many of these techniques are too expensive to be implemented for routine screening. Diffuse optical tomography (DOT) promises to provide a low-cost method for routine, non-invasive cancer screening. Unfortunately, the absence of appropriate imaging technologies for the high-frequency modulation techniques employed by DOT severely limits the spatial resolution and constrains the diagnostic value of DOT. This program resolves these limitations by developing a fully integrated, nearlR digital camera chip, which is an application specific integrated circuit (ASIC), that counts photons using Geiger avalanche photodiodes. This all-digital, CMOS (complementary-symmetry metal-oxide-semiconductor) imaging technology fulfills the demanding requirements for providing high-resolution DOT images. In Phase I, we will explore appropriate fabrication architectures for the ASIC and fabricate prototype pixel elements, along with the critical circuit components needed to support the pixel element. We will test the prototype devices and compare their measured performance to the initial design specifications.

描述（由申请人提供）： 早期检测和常规临床筛查是预防癌症死亡的第一道防线，一种疾病占551,833，在2000年在美国生活。但是，许多这些技术太昂贵了，无法实施常规筛选。弥漫性光学断层扫描（DOT）有望为常规的非侵入性癌症筛查提供低成本的方法。不幸的是，对于DOT所采用的高频调制技术缺乏适当的成像技术会严重限制空间分辨率并限制DOT的诊断值。 该程序通过开发完全集成的，近使数码相机芯片（ASIC）来解决这些局限性，该芯片是一个特定于应用的集成电路（ASIC），该电路使用Geiger Avalanche Photodiodes计数光子。这种全数字的CMO（互补的金属 - 氧化物 - 氧化物 - 氧化物 - 氧化物 - 氧化物）成像技术满足了提供高分辨率点图像的苛刻要求。在第一阶段，我们将探索ASIC和制造原型像素元素的适当制造体系结构，以及支持像素元素所需的关键电路组件。我们将测试原型设备，并将其测量性能与初始设计规范进行比较。