Development of Instrumentation for High-Rate Production of Hyperpolarized 3He Gas

超极化 3He 气体高速生产仪器的开发

• 批准号: 7362394
• 负责人: RONALD L WALSWORTH
• 金额: $ 16.37万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7362394
• 关键词: Aluminum; Alveolar; Amplifiers; Biomedical Engineering; Biomedical Research; Breathing; Cells; Characteristics; Clinical; Clinical Research; Complex; Computers; Condition; Coupled; Development; Devices; Diagnostic; Diffusion; Dimensions; Electronics; Environment; Environmental air flow; Equipment; European; Funding; Funding Mechanisms; Gases; Glass; Guidelines; Helium; Hospitals; Hour; Human; Image; Imaging Techniques; In Situ; Institutes; Internet; Laboratories; Lasers; Life; Light; Lung; Lung diseases; Magnetic Resonance Imaging; Magnetism; Maps; Medicine; Methods; Nature; Noble Gases; Nuclear; Numbers; Operating System; Operative Surgical Procedures; Optics; Perfusion; Physicians; Physics; Physiological; Physiology; Process; Production; Pump; Purpose; Qualifying; Rate; Relaxation; Research; Resolution; Rubidium; Sampling; Science; Signal Transduction; Stainless Steel; Structure; System; Techniques; Technology; Teflon; Testing; Time; United States National Institutes of Health; Vacuum; Variant; Work; analog; base; bioimaging; cost; design; gas analyzer; instrument; instrumentation; interest; laptop; lung imaging; magnetic field; multidisciplinary; novel; physical science; polarimetry; polyfunctional aziridine; pressure; programs; prototype; technology development

DESCRIPTION (provided by applicant): The broad objective of this proposal is to develop a novel, rapid, robust and portable 3He hyperpolarization apparatus that will produce ~ 1 L / hour of 3He gas spin-polarized to 40% or greater. The apparatus will use the metastability-exchange optical pumping method (MEOP), a theoretically-favorable process that has traditionally been difficult to implement. Recent advances in compressor and laser technology have overcome these hurdles. A polarizer based on the MEOP process will provide an almost ten-fold increase in production rate for hyperpolarized 3He when compared to current polarizer technology based on the alternative spinexchange optical-pumping method (SEOP). The proposed apparatus will be the first MEOP 3He hyperpolarization apparatus dedicated to biomedical MRI use in the US and which can be located in the biomedical imaging environment. This multidisciplinary program bridges the physical and biomedical sciences, with the potential to provide significant breakthrough research in pulmonary physiology and medicine. Thus this program qualifies for the R-21 funding mechanism. The Specific Aims of the program are: 1. Design and fabricate a prototype 3He hyperpolarization apparatus that operates using the metastabilityexchange optical pumping (MEOP) method, and produces ~ 1 L per hour of 40% polarized 3He gas. 2. Determine optimum operating conditions for the apparatus, studying 3He polarization signal as a function of operating parameters, including gas mixture, pressure, and compression rate. 3. Perform phantom 3He MRI studies with gas from the MEOP 3He hyperpolarization apparatus.

描述（由申请人提供）：该提案的广泛目标是开发一种新型，快速，健壮和便携式3HE超极化设备，该设备将产生约1 L /小时的3HE气体自旋至40％或更高的气体。该设备将使用亚稳定性 - 交换光学泵送方法（MEOP），这是一个理论上有利的过程，传统上很难实施。压缩机和激光技术的最新进展克服了这些障碍。基于替代性spinexchange光泵化方法（SEOP），基于MEOP工艺的偏振器将为超极化3HE的生产率提高近十倍。所提出的设备将是美国第一个莫多尔的超极化设备，用于美国在美国使用生物医学MRI，并且可以位于生物医学成像环境中。该多学科计划桥接了物理和生物医学科学，有可能在肺部生理学和医学方面提供重大突破性研究。因此，该计划有资格获得R-21资金机制。该计划的具体目的是： 1。设计和制造一个3HE超极化设备，该设备使用马稳定性旋转光学泵（MEOP）方法运行，并且每小时约1升每小时40％极化3HE气体。 2。确定设备的最佳操作条件，研究3HE极化信号是操作参数的函数，包括气体混合物，压力和压缩速率。 3。通过Meop 3HE超极化设备中的气体进行幻影3HE MRI研究。

项目成果

Posture-dependent human 3He lung imaging in an open-access MRI system: initial results.

开放式 MRI 系统中依赖姿势的人类 3He 肺部成像：初步结果。

• DOI: 10.1016/j.acra.2007.10.010
• 发表时间: 2008
• 期刊: Academic radiology
• 影响因子: 4.8
• 作者: Tsai,LeoL;Mair,RossW;Li,Chih-Hao;Rosen,MatthewS;Patz,Samuel;Walsworth,RonaldL
• 通讯作者: Walsworth,RonaldL