Rapid Diagnostic Testing of Urinary Tract Infections

尿路感染的快速诊断检测

• 批准号: 7106813
• 负责人: Ronald J Rieder
• 金额: $ 10万
• 依托单位: BIOSENSE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-18 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106813
• 关键词: Escherichia coli; antibiotics; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; communicable disease diagnosis; diagnosis design /evaluation; diagnostic tests; drug resistance; electrical impedance; electrical measurement; rapid diagnosis; urinalysis; urinary tract disorder diagnosis; urinary tract infection

DESCRIPTION (provided by applicant): The development of a new rapid diagnostic method for testing the antibiotic susceptibility of urinary tract infections is proposed. The technical approach is based on a novel implementation of impedance sensing to monitor cellular growth with exceptional sensitivity and stability avoiding the need for grown cultures to obtain results. Susceptibility results can be obtained directly from urinary specimens at the point of care within two hours reducing the time from sample collection to availability by days enabling targeted therapy, improved patient outcomes, and the reduced spread and generation of resistant organisms. The method can be realized with a disposable device that is simple, cost effective, and ideal for mass production. Feasibility of the proposed diagnostic tool will be demonstrated with both drug susceptible and resistant strains of Escherichia coli. A follow-on effort will focus on the development of prototype instrumentation and testing of other clinically relevant multi-drug resistant organisms.

描述（由申请人提供）：建议开发一种新的快速诊断方法来测试尿路感染的抗生素敏感性。该技术方法基于阻抗传感的新颖实现，以卓越的灵敏度和稳定性监测细胞生长，避免了需要生长培养物才能获得结果。可以在两小时内直接从护理点的尿液样本中获得药敏结果，从而将样本采集到可用的时间缩短数天，从而实现靶向治疗、改善患者结果并减少耐药微生物的传播和产生。该方法可以使用一次性装置来实现，该装置简单、成本有效并且非常适合大规模生产。所提出的诊断工具的可行性将通过药物敏感和耐药菌株的大肠杆菌来证明。后续工作将集中于原型仪器的开发和其他临床相关多重耐药生物体的测试。