Core-Statistical and Economic Analysis

核心统计与经济分析

• 批准号: 7525155
• 负责人: Adriana Perez
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7525155
• 关键词: biomedical facility; community; health disparity; molecular biology

PARENT ABSTRACT (CORE ABSTRACT NOT PROVIDED) The broad objective is to determine prevalence of obesity and type 2 diabetes in Hispanic adolescents. Relationships between these two health problems and factors that contribute to them will be analyzed. Besides providing information to design prevention interventions, this pilot will record baseline data before implementation of a comprehensive children's health program in the school system. After a cohort has encountered this program, the study can be repeated to evaluate its effects. The specific aims of the program are to obtain baseline data, to determine relationships between adiposity, biological markers of type 2 diabetes, behavioral and socioeconomic factors in the development of obesity, to suggest possible prevention interventions, and to use the data to evaluate current and future interventions. The study takes place in Brownsville, on the Texas Mexico border, where the population is 84.8% Hispanic. This community has an average income half that of the rest of the United States, but high disease burdens, particularly chronic diseases such as diabetes. The study population will consist of 474 9th to 12th grade students who are randomly selected. A Type I error level of 0.05, standard deviation of 6.4 BMI units will be assumed and 474 non-respondents will be interviewed. Height, weight, Body Impedance Analysis, blood pressure, acanthosis nigricans, fasting plasma glucose, insulin, lipid profile, C-reactive protein, liver function tests, demographic factors, physical activity and nutritional habits will be recorded. Results from these tests will be shared with the parents of the child. Summary measures (means, median, mode, variability measurements: standard deviation, range, interquartile range, etc.) will be determined. The data will be shared with the Cardiovascular Core for use in evaluation of the effectiveness of their interventions. The Statistical Economic Analysis Core (SEAC) will provide data analyses. A database will contain data from the clinical examination, questionnaire and laboratory. The findings will be analyzed to determine the prevalence of overweight and obese children, type 2 diabetes and association of risk factors. These analyses will be shared with other researchers at the HHRC, with the community, and used to design interventions. A second database will be built to enter data from the non-responder parents.

父摘要（未提供核心摘要） 总体目标是确定西班牙裔青少年肥胖和 2 型糖尿病的患病率。 将分析这两个健康问题之间的关系以及导致它们的因素。 除了提供设计预防干预措施的信息外，该试点项目还将在学校系统实施全面的儿童健康计划之前记录基线数据。 在一群人经历过该计划后，可以重复该研究以评估其效果。该计划的具体目标是获取基线数据，确定肥胖、2 型糖尿病的生物标志物、肥胖发展中的行为和社会经济因素之间的关系，提出可能的预防干预措施，并利用这些数据评估当前和未来的干预措施。 这项研究在德克萨斯州与墨西哥边境的布朗斯维尔进行，那里的人口 84.8% 是西班牙裔。这个社区的平均收入是美国其他地区的一半，但疾病发病率很高 负担，特别是糖尿病等慢性病。研究人群将由随机选择的 474 名 9 至 12 年级学生组成。假设 I 类错误水平为 0.05，标准差为 6.4 BMI 单位，并对 474 名非受访者进行访谈。记录身高、体重、身体阻抗分析、血压、黑棘皮症、空腹血糖、胰岛素、血脂、C反应蛋白、肝功能检查、人口因素、体力活动和营养习惯。这些测试的结果将与孩子的父母分享。 将确定汇总测量（均值、中位数、众数、变异性测量：标准差、极差、四分位距等）。这些数据将与心血管核心共享，用于评估其干预措施的有效性。统计经济分析核心（SEAC）将提供数据分析。数据库将包含来自临床检查、问卷调查和实验室的数据。 将对调查结果进行分析，以确定超重和肥胖儿童、2 型糖尿病的患病率以及危险因素的关联。这些分析将与 HHRC 的其他研究人员和社区共享，并用于设计干预措施。将建立第二个数据库来输入来自无反应者父母的数据。